{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:11:14Z","timestamp":1768263074466,"version":"3.49.0"},"reference-count":0,"publisher":"Undersea and Hyperbaric Medical Society (UHMS)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UHM"],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:p>Objectives: To clinically and microbiologically evaluate the effects of hyperbaric oxygen (HBO2) therapy in addition to full-mouth ultrasonic subgingival debridement (FM-UD), in the initial treatment of chronic periodontitis.\u00a0  Methods: Twenty patients presenting moderate to severe generalized forms of chronic periodontitis were included in a three-month randomized, parallel-group, single-blinded, prospective study. At baseline patients were randomly assigned to two treatment groups [Test Group (FM-UD+HBO2) and Control Group (FM-UD)]. Both groups were treated with an FM-UD session. Ten HBO2 sessions (one session per day for 10 days at a pressure of 2.5 ATA) were additionally administered to the Test Group. Soft tissues parameters [probing pocket depth (PPD), bleeding on probing (BOP), clinical attachment level (CAL) and visible plaque index (VPI)] were assessed at baseline (immediately before FM-UD treatment), after two weeks, after six weeks and at three months. For each patient, a site presenting PPD\u00a0\u2265\u00a06mm and positive BOP was selected as a qualifying site (QS), to be monitored clinically (at T0, T1, T2 and T3) and microbiologically (at T0, T1 and T3).  Results: There were no statistically significant differences between the two groups for any clinical parameter analyzed after three months, except for BOP, which was significantly (p &lt; 0.05) reduced in the Test Group. Reductions in bacterial levels were detected in both groups after therapy. Faster bacterial recolonization occurred after three months in the Control Group.  Conclusion: HBO2 therapy in combination with FM-UD may represent an efficacious approach to the treatment of moderate to severe forms of periodontitis.<\/jats:p>","DOI":"10.22462\/10.12.2020.6","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T20:14:13Z","timestamp":1609359253000},"page":"571-580","source":"Crossref","is-referenced-by-count":11,"title":["Hyperbaric oxygen therapy for the treatment of moderate to severe periodontitis: a clinical pilot study"],"prefix":"10.22462","author":[{"name":"Dentistry and Maxillofacial Surgery Section, Department of Surgery, Dentistry, Pediatrics and Gynecology (DIPSCOMI), University of Verona, Verona, Italy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Lombardo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dentistry and Maxillofacial Surgery Section, Department of Surgery, Dentistry, Pediatrics and Gynecology (DIPSCOMI), University of Verona, Verona, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Signoretto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Microbiology Section, Department of Diagnostics and Public Health, University of Verona, Verona, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annarita","family":"Signoriello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dentistry and Maxillofacial Surgery Section, Department of Surgery, Dentistry, Pediatrics and Gynecology (DIPSCOMI), University of Verona, Verona, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Simeoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dentistry and Maxillofacial Surgery Section, Department of Surgery, Dentistry, Pediatrics and Gynecology (DIPSCOMI), University of Verona, Verona, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Rovera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Institute of Dentistry, Queen Mary University of London, London United Kingdom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Francesco","family":"Nocini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dentistry and Maxillofacial Surgery Section, Department of Surgery, Dentistry, Pediatrics and Gynecology (DIPSCOMI), University of Verona, Verona, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9754","published-online":{"date-parts":[[2020,10,1]]},"container-title":["Undersea and Hyperbaric Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T20:14:14Z","timestamp":1609359254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.uhms.org\/uhm-search\/uhm-journal-volume-47-2020\/number-4\/hyperbaric-oxygen-therapy-for-the-treatment-of-moderate-to-severe-periodontitis-a-clinical-pilot-study.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22462\/10.12.2020.6","relation":{},"ISSN":["1066-2936"],"issn-type":[{"value":"1066-2936","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,1]]}}}