{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T04:56:20Z","timestamp":1723006580466},"reference-count":0,"publisher":"Undersea and Hyperbaric Medical Society (UHMS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UHM"],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:p>Purpose: To determine the effects of a blockade of nitric oxide (NO) synthesis on hyperbaric oxygen (HBO2) therapy during cyanide (CN) intoxication.  Methods: 39 anesthetized female Sprague-Dawley rats were exposed to CN intoxication (5.4 mg\/kg intra-arterially) with or without previous nitric oxide synthase (NOS) inhibition by L-NG-nitroarginine methyl ester (L-NAME) injection (40 mg\/kg intraperitoneally). Subsequently, either HBO2 therapy (284 kPa\/90 minutes), normobaric oxygen therapy (100% oxygen\/90 minutes) or nothing was administered. Intracerebral microdialysis was used to measure the interstitial brain concentration of lactate, glucose, glycerol and lactate\/pyruvate ratios.   Results: L-NAME potentiated CN intoxication by higher maximum and prolonged lactate (in mM: 0. 5+\/- 0.3 vs. 0.7 +\/- 0.4, P &lt; 0.005) concentrations compared with solely CN-intoxicated rats. The same trend was found for mean glucose, glycerol and lactate\/pyruvate ratio levels.During HBO2 treatment a sustained reduction occurred in mean lactate levels (in mM: 0.5 +\/- 0.5 vs. 0.7 +\/- 0.4, P &lt; 0.01) regardless of NOS blockade by L-NAME. The same trend was found for mean glucose and glycerol levels.  Conclusion: The results suggest that blocking NOS using L-NAME can worsen acute CN intoxication. HBO2 treatment can partially overcome this block and continue to ameliorate CN intoxication.<\/jats:p>","DOI":"10.22462\/5.6.2017.3","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:31:25Z","timestamp":1514939485000},"page":"221-234","source":"Crossref","is-referenced-by-count":0,"title":["Hyperbaric oxygen therapy may overcome nitric oxide blockage during cyanide intoxication"],"prefix":"10.22462","volume":"44","author":[{"name":"Centre and Laboratory of Hyperbaric Medicine, Department of Anesthesia, Center of Head- and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen \u00d8, Denmark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Polzik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Bo","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Centre and Laboratory of Hyperbaric Medicine, Department of Anesthesia, Center of Head- and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen \u00d8, Denmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Vidiendal","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Neuroscience and Pharmacology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen \u00d8, Denmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Neuroanaesthesia, the Neuroscience Center, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen O, Denmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav","family":"Gr\u00f8ndal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Hyldegaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Centre and Laboratory of Hyperbaric Medicine, Department of Anesthesia, Center of Head- and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen \u00d8, Denmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9754","published-online":{"date-parts":[[2017,5,1]]},"container-title":["Undersea and Hyperbaric Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T19:38:46Z","timestamp":1666294726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.uhms.org\/uhm-search\/uhm-journal-volume-44\/number-3\/hyperbaric-oxygen-therapy-may-overcome-nitric-oxide-blockage-during-cyanide-intoxication.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,5,1]]},"published-print":{"date-parts":[[2017,5,1]]}},"URL":"https:\/\/doi.org\/10.22462\/5.6.2017.3","relation":{},"ISSN":["1066-2936"],"issn-type":[{"type":"print","value":"1066-2936"}],"subject":[],"published":{"date-parts":[[2017,5,1]]}}}