{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:06:09Z","timestamp":1788242769674,"version":"build-2803163510"},"reference-count":0,"publisher":"MRE Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>Testicular ischemia reperfusion (I\/R) injury is a significant urological problem where clinical interventions may be inadequate, and the antioxidants might be potential co-treatment modalities. This study examined the gonadoprotective effect of trans-Anethole in testicular I\/R injury. Twenty-eight male rats were divided into four groups. Rats in the I\/R, I\/R + t100, I\/R + t200 groups underwent bilateral testicular I\/R injury. The I\/R + t100 and I\/R + t200 groups received 100 or 200 mg\/kg trans-Anethole at the 2nd hour of ischemia. Microscopic evaluations demonstrated that testicular I\/R injury leads to severe testicular degeneration. Tissue oxidative stress, pro-apoptotic Bcl-2 associated X (Bax) and Caspase 3, pro-inflammatory Tumor necrosis factor-alpha (TNF-\u03b1), Interleukin-1 beta (IL-1\u03b2) and Interleukin 6 (IL-6) cytokines levels were significantly (p &lt; 0.05) upregulated when compared to the Control group. Additionally, transcription factors Signal transducer and activator of transcription 3 (STAT3) and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-\u03baB) levels increased significantly (p &lt; 0.05) compared to the Control group. Tissue disrupted parameters in the I\/R + t200 group were significantly different (p &lt; 0.05) from the I\/R group, contrasting with the slight improvement in the I\/R + t100 group. The STAT3 and NF-\u03baB expression levels in the I\/R + t200 group were significantly suppressed (p &lt; 0.05) compared to the I\/R group. In conclusion, our study indicates that trans-Anethole could enhance gonadoprotective activity in testicular I\/R injury, potentially involving transcription factors STAT3 and NF-\u03baB. However, before the consumption of trans-Anethole-containing natural or manufactured goods, the potential benefits and side effects should be carefully evaluated.<\/jats:p>","DOI":"10.22514\/j.androl.2024.015","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T05:04:38Z","timestamp":1723698278000},"source":"Crossref","is-referenced-by-count":5,"title":["Regulation of STAT3 and NF-\u03baB signaling pathways by trans-Anethole in testicular ischemia-reperfusion injury and its gonadoprotective effect"],"prefix":"10.22514","member":"26027","published-online":{"date-parts":[[2024]]},"container-title":["Revista Internacional de Androlog\u00eda"],"original-title":[],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T17:43:13Z","timestamp":1772473393000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.intandro.com\/articles\/10.22514\/j.androl.2024.015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22514\/j.androl.2024.015","relation":{},"subject":[],"published":{"date-parts":[[2024]]}}}