{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:27:44Z","timestamp":1718411264892},"reference-count":0,"publisher":"MRE Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>The coronavirus disease 2019 (COVID-19) and temporomandibular joint disorders (TMD) as the two major diseases are being focused by the public in modern societies. Previous epidemiological studies have shown increase in TMD prevalence during COVID-19 pandemic era. This study was aimed to verify the causal association between two sides using bidirectional mendelian randomization (MR) analysis. It explored whether COVID-19 could cause TMD or TMD influenced the COVID-19 susceptibility. Furthermore it was aimed to eliminate the reverse relationship and other confounders, and an attempt was made to provide etiologic evidence. Single-nucleotide polymorphisms (SNPs) related to three COVID-19 phenotypes (p &lt; 5 \u00d7 10\u22128) were selected from the genome-wide association study (GWAS) data collected through COVID-19 host genetics initiative (HGI). SNPs related to TMD (p &lt; 5 \u00d7 10\u22126) were collected from GWAS data in UK Biobank (UKB). Inverse variance weighted (IVW), weighted median (WM), and MR-Egger regression estimated the causal effect between two sides in this study. Furthermore, four sensitivity analyses (MR-PRESSO, Cochran\u2019s Q test, MR-Egger intercept test, and leave-one-out test) were used to confirm the robust results. TMD-related GWAS in FinnGen repeated the MR to validate the results. COVID-19 was not affected by TMD. The reversed MR suggested no significant causal effect of COVID-19 on TMD. Sensitivity analyses showed no gene pleiotropy and had robust results in this MR. Nonetheless, the MR statistical power was &lt;80%, which suggested insufficient sample size of COVID-19 and TMD. This study based on current evidence depicted that COVID-19 had no impact on TMD, and TMD did not increase the susceptibility of severe acute respiratory syndrome coronavirus-2. During COVID-19 pandemic, excessive psychological stress caused by COVID-19 might act as a mediator between the two diseases. The relationship between the two sides needs verification by more external studies in the future.<\/jats:p>","DOI":"10.22514\/jofph.2024.018","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:27:06Z","timestamp":1718346426000},"source":"Crossref","is-referenced-by-count":0,"title":["Is there a causal association between temporomandibular disorders and COVID-19 risk? A genetic instrumental variables analysis"],"prefix":"10.22514","member":"26027","published-online":{"date-parts":[[2024]]},"container-title":["Journal of Oral &amp; Facial Pain and Headache"],"original-title":[],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:27:08Z","timestamp":1718346428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jofph.com\/articles\/10.22514\/jofph.2024.018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22514\/jofph.2024.018","relation":{},"ISSN":["2333-0376","2333-0384"],"issn-type":[{"value":"2333-0376","type":"electronic"},{"value":"2333-0384","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}