{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T04:14:22Z","timestamp":1741839262281,"version":"3.38.0"},"reference-count":0,"publisher":"MRE Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: Vitamin D has roles in neurological, hormonal and immunological processes, affecting various pain disorders and related comorbidities. The aim of this study was to investigate relationship between vitamin D levels and clinical features in postmenopausal females with burning mouth syndrome (BMS). Methods: This retrospective, cross-sectional study reviewed clinical and laboratory data from 144 postmenopausal females with BMS. Laboratory tests measured 25-(OH) hydroxyvitamin D, hematic components and inflammatory markers. Participants were categorized by serum levels of 25-(OH) hydroxyvitamin D, as deficient (&lt;20 ng\/mL), inadequate (20\u201330 ng\/mL), and adequate (&gt;30 ng\/mL). Pain intensity and oral health-related quality of life were assessed using visual analog scale (VAS), McGuill Pain Questionnaire (MPQ) and Oral Health Impact Profile-49 (OHIP-49). Results: Pain intensity and oral health-related quality of life were associated with serum vitamin D levels. Hemoglobin, folic acid and high-sensitivity C-reactive protein (hs-CRP) concentrations varied among groups. Serum 25-(OH) hydroxyvitamin D levels showed negative correlation with VAS, MPQ sensory, MPQ affective, MPQ evaluative and OHIP-49 scores, indicating lower pain intensity and suffering with higher vitamin D levels. Additionally, iron levels were negatively related to VAS score, while folic acid levels were negatively associated with OHIP-49 score. Serum 25-(OH) hydroxyvitamin D levels were negatively correlated with hs-CRP levels. Conclusions: These findings suggest significant interactions between 25-(OH) hydroxyvitamin D levels and pain intensity and suffering and oral health-related quality of life, indicating its therapeutic potential for postmenopausal BMS patients.<\/jats:p>","DOI":"10.22514\/jofph.2025.008","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:27:07Z","timestamp":1741771627000},"source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D as a modulator of pain and inflammation in postmenopausal females with burning mouth syndrome"],"prefix":"10.22514","member":"26027","published-online":{"date-parts":[[2025]]},"container-title":["Journal of Oral &amp; Facial Pain and Headache"],"original-title":[],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:27:07Z","timestamp":1741771627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jofph.com\/articles\/10.22514\/jofph.2025.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22514\/jofph.2025.008","relation":{},"ISSN":["2333-0376","2333-0384"],"issn-type":[{"value":"2333-0376","type":"electronic"},{"value":"2333-0384","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}