{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T04:04:17Z","timestamp":1749787457108,"version":"3.41.0"},"reference-count":0,"publisher":"MRE Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: This study aims to elucidate the causal relationships between 1400 blood metabolites and pain related to temporomandibular disorders (TMD) using Mendelian Randomization (MR) analysis. Methods: Utilizing data from genome-wide association studies (GWAS), our analysis was conducted with R software using the \u201cTwoSampleMR\u201d package. The primary method applied was Inverse Variance Weighted (IVW) analysis, which was supplemented with MR-Egger, Weighted Median, Simple Mode and Weighted Mode methods to examine the causal impact of blood metabolites on TMD-associated pain. We also assessed heterogeneity and the presence of horizontal pleiotropy using MR-Egger regression, MR-PRESSO (MR Pleiotropy Residual Sum and Outlier) global tests, and MR-Egger intercept tests. Results: Three metabolites\u2014Acetylcarnitine, Propionylcarnitine (c3) and X-24241\u2014were significantly associated with TMD-related pain. Specifically, Acetylcarnitine had an odds ratio (OR) of 1.409 (95% CI (confidence intervals): 1.016\u20131.954, p = 0.04), Propionylcarnitine (c3) had an OR of 1.194 (95% CI: 1.036\u20131.377, p = 0.014), and X-24241 had an OR of 1.408 (95%CI: 1.108\u20131.790, p = 0.005). Conclusions: This study establishes a causal link between increased levels of these three metabolites and TMD-related pain. Our findings provide new insights into the pathogenesis of TMD and potential therapeutic targets.<\/jats:p>","DOI":"10.22514\/jofph.2025.034","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:46:05Z","timestamp":1749717965000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic prediction of blood metabolites and causal relationships with pain associated with temporomandibular disorders: a Mendelian randomization study"],"prefix":"10.22514","member":"26027","published-online":{"date-parts":[[2025]]},"container-title":["Journal of Oral &amp; Facial Pain and Headache"],"original-title":[],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:46:06Z","timestamp":1749717966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jofph.com\/articles\/10.22514\/jofph.2025.034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22514\/jofph.2025.034","relation":{},"ISSN":["2333-0376","2333-0384"],"issn-type":[{"value":"2333-0376","type":"electronic"},{"value":"2333-0384","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}