{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T04:04:17Z","timestamp":1749787457312,"version":"3.41.0"},"reference-count":0,"publisher":"MRE Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: To examine whether the combination of ultrasound (US)-guided superior cervical ganglion (SCG) block with standard triptans has a superior relief of headache as compared to triptans alone for acute migraine. Methods: The retrospective-prospective cohort study enrolled patients presenting with acute migraine. The records of 243 cases receiving standard triptans and an adjunctive US-guided SCG were reviewed, while 230 cases were prospectively enrolled to receive triptan alone for control after age and sex matching in a 1:1.2 ratio. The primary endpoint was sustained headache relief and complete freedom from pain within post-procedural 24 hours. Secondary outcomes included headache relief and freedom from pain at 2 hours, monthly migraine days (MMDs), migraine disability assessment (MIDAS) scores, migraine-specific quality of life questionnaire (MSQ) scores, need for rescue analgesics use and adverse events. Results: Sustained headache relief was observed in 69.5% of cases in the SCG cohort, yielding a superior outcome increased by 21.7% (95% confidence interval (CI): 13.1%, 30.4%) (p &lt; 0.001). Overall, SCG block plus triptans had a better effect on headache relief and freedom from pain at post-procedural 2 hours, and sustained freedom from headache within 24 hours compared to triptans alone. At 1-month visit, SCG cohort also showed a greater improvement in MMDs (p &lt; 0.01), MIDAS scores (p = 0.040) and MSQ scores (p = 0.036). No major adverse events were observed. Conclusions: There was a superior therapeutic effectiveness of US-guided SCG block in conjunction with standard triptans for better headache relief up to post-procedural 1 month in acute migraine. It had an adjunctive beneficial effect in functional ability, life quality and possible facilitation of avoiding more adverse events.<\/jats:p>","DOI":"10.22514\/jofph.2025.038","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:46:08Z","timestamp":1749717968000},"source":"Crossref","is-referenced-by-count":0,"title":["Combination effect of ultrasound-guided superior cervical ganglion block and standard triptan for migraine attacks"],"prefix":"10.22514","member":"26027","published-online":{"date-parts":[[2025]]},"container-title":["Journal of Oral &amp; Facial Pain and Headache"],"original-title":[],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:46:08Z","timestamp":1749717968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jofph.com\/articles\/10.22514\/jofph.2025.038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22514\/jofph.2025.038","relation":{},"ISSN":["2333-0376","2333-0384"],"issn-type":[{"value":"2333-0376","type":"electronic"},{"value":"2333-0384","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}