{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:44:58Z","timestamp":1785408298478,"version":"3.56.0"},"reference-count":0,"publisher":"MRE Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,12]]},"abstract":"<jats:p>Background: Polypharmacy is common in headache medicine. This project uses DrugBank and Food and Drug Administration\u2019s (FDA) Adverse Event Reporting System (FAERS) to determine the likelihood of a theoretical and empirically reported interaction between a given number of headache abortive and preventive medications. Methods: All headache medications referenced in \u201cThe American Headache Society Position Statement on Integrating New Migraine Treatments into Clinical Practice\u201d and Szperka\u2019s \u201cMigraine care in the era of COVID-19: clinical pearls and plea to insurers\u201d were included. All possible combinations of up to three abortives and preventatives were screened for drug-drug interactions through searches in DrugBank and FAERS. If at least one drug-drug interaction was listed, then it was included in our analysis. The percentage of combinations containing an interaction was then compared across the two databases. Results: Of the 38 abortives and 23 preventives included, once more than 3 drugs are used in any combination, a drug-drug interaction was &gt;99% likely, per DrugBank. However, per FAERS, the reported interaction was 39% to 60% likely once 3 or 4 drugs are used in any combination. In FAERS, the likelihood of interaction rised most dramatically once 3 or more drugs are used. Conclusions: Theoretical interactions, based on DrugBank, maybe overstated when compared to actual observed interactions in FAERS. Future direction is needed delving into the types of interactions recorded in each database.<\/jats:p>","DOI":"10.22514\/jofph.2025.073","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:29:59Z","timestamp":1765528199000},"page":"165","source":"Crossref","is-referenced-by-count":0,"title":["Estimating risk of reported versus theoretical drug-drug interactions in headaches medicine: an exhaustive comparison between DrugBank and FAERS database for abortive and preventive combinations"],"prefix":"10.22514","author":[{"given":"Victor","family":"Kaytser","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05byvp690","id-type":"ROR","asserted-by":"publisher"}],"name":"The University of Texas Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26027","published-online":{"date-parts":[[2025,12,12]]},"container-title":["Journal of Oral &amp; Facial Pain and Headache"],"original-title":[],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:30:00Z","timestamp":1765528200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jofph.com\/articles\/10.22514\/jofph.2025.073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22514\/jofph.2025.073","relation":{},"ISSN":["2333-0384","2333-0376"],"issn-type":[{"value":"2333-0384","type":"print"},{"value":"2333-0376","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]}}}