{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Authorea, Inc."}],"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:36:59Z","timestamp":1748968619801,"version":"3.41.0"},"posted":{"date-parts":[[2022,8,2]]},"group-title":"Preprints","reference-count":0,"publisher":"Wiley","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,8,2]]},"abstract":"<jats:p id=\"p1\"><jats:bold>BACKGROUND<\/jats:bold>: Although cardiac resynchronization therapy (CRT) is\nbeneficial in most heart failure patients, up to 40% do not respond to\nCRT. It has been suggested that multipoint left ventricle pacing (MPP)\nwould increase the response rate. <jats:bold>AIM<\/jats:bold>: To assess the CRT\nresponse rate at 6 months in patients implanted with a CRT device with\nthe MPP feature activated early after the implant. <jats:bold>METHODS<\/jats:bold> This\nwas a multicentre, prospective, open-label and non-randomized study. The\nprimary endpoint was response to biventricular pacing defined as\n&gt;15% relative reduction in left ventricular end-systolic\nvolume (LVESV) comparing echocardiography measurements performed at\nbaseline and 6 months by a core laboratory. Among secondary endpoints\nthe combined endpoint of mortality or all-cause hospitalizations was\nevaluated. Primary study endpoint and clinical outcomes were compared to\na Quarto II control cohort. <jats:bold>RESULTS:<\/jats:bold> 105 patients were\nincluded. The response rate was 64.6% (97.5% lower confidence bound\n53%). Mean relative reduction in LVESV was 25.3% and mean absolute\nincrease in LVEF was 9.4%. The subjects with device programmed using\nanatomical approach had showed a trend toward higher responder rate than\nthose using the electrical approach (72% vs. 61.1%, p= 0.32). Compared\nwith Quarto II, the combined endpoint of mortality and or all-cause\nhospitalizations was lower in Quarto III (12.4% vs 25.4%, p=0.004).\n<jats:bold>CONCLUSIONS<\/jats:bold>: Early activation of MPP was not associated to an\nadvantage increasing echocardiography responders to CRT at 6 months of\nfollow up. Nevertheless, MPP was associated with better clinical\noutcomes in comparison to a historical control cohort. Patients\nprogrammed using widest pacing cathodes had a numerically higher\nresponder rate.<\/jats:p>","DOI":"10.22541\/au.165942197.71081026\/v1","type":"posted-content","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T06:32:58Z","timestamp":1659421978000},"source":"Crossref","is-referenced-by-count":0,"title":["QUARTO III. Response rate in cardiac resynchronization therapy patients implanted with a left ventricular quadripolar lead and the MultiPoint TM Pacing feature activated."],"prefix":"10.22541","author":[{"given":"Joaqu\u00edn","family":"Osca","sequence":"first","affiliation":[{"name":"Hospital Universitari i Politecnic La Fe"}]},{"given":"Jaume","family":"Francisco-Pascual","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d'Hebron"}]},{"given":"Javier","family":"Mart\u00ednez-Basterra","sequence":"additional","affiliation":[{"name":"Clinica Universidad de Navarra"}]},{"given":"Juan Gabriel","family":"Martinez","sequence":"additional","affiliation":[{"name":"Hospital General Universitari d'Alacant"}]},{"given":"Hip\u00f3lito","family":"Reis","sequence":"additional","affiliation":[{"name":"Hospital de Santo Antonio dos Capuchos"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8371-8354","authenticated-orcid":true,"given":"Mario","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Hospital Santa Marta"}]},{"given":"Bieito","family":"Campos","sequence":"additional","affiliation":[{"name":"Hospital Universitari Arnau de Vilanova"}]},{"given":"Javier","family":"Balaguer","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Guadalajara"}]},{"given":"Jer\u00f3nimo Rubio","family":"Sanz","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario de Valladolid Servicio de Cardiologia"}]},{"given":"Ricardo","family":"Pav\u00f3n-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Valme"}]},{"given":"Julio Hern\u00e1ndez","family":"Afonso","sequence":"additional","affiliation":[{"name":"Hospital Universitario Nuestra Senora de la Candelaria"}]},{"given":"Jose Miguel","family":"Ormaetxe","sequence":"additional","affiliation":[{"name":"Hospital Universitario Basurto"}]},{"given":"Jose","family":"Zamorano","sequence":"additional","affiliation":[{"name":"MDLZ Espana Madrid"}]},{"given":"Pilar","family":"Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Abbott Cardiovascular Espana SA"}]},{"given":"Javier","family":"Alzueta","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Victoria"}]}],"member":"311","container-title":[],"original-title":[],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T06:32:58Z","timestamp":1659421978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.authorea.com\/users\/395764\/articles\/579490-quarto-iii-response-rate-in-cardiac-resynchronization-therapy-patients-implanted-with-a-left-ventricular-quadripolar-lead-and-the-multipoint-tm-pacing-feature-activated?commit=7d205bb917f98a489c1b29ca4a7335bce4b01504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22541\/au.165942197.71081026\/v1","relation":{},"subject":[],"published":{"date-parts":[[2022,8,2]]},"subtype":"preprint"}}