{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:14:44Z","timestamp":1778678084563,"version":"3.51.4"},"posted":{"date-parts":[[2023,5,29]]},"reference-count":0,"publisher":"Wiley","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                  Researchers and engineers came together in Lisbon at the 27\n                  <jats:sup>th<\/jats:sup>\n                  Meeting of the European Society for Animal Cell\nTechnology (ESACT 2022), to discuss the latest advances in technologies\nassociated with protein-based biologics production, new modalities and\ncell, gene and tissue therapies. Main contributions focused on how the\ncapabilities of production platforms can be enhanced, and how to\nleverage them to generate new products. Some of the advances that were\npresented are discussed below, including those related with cell line\ndevelopment, metabolic engineering, analytics, CHO and insect cells\nplatforms engineering, vesicle and viral vector production, and gene and\ncell therapy, along with some concluding remarks on the future of this\nimportant field.\n                <\/jats:p>","DOI":"10.22541\/au.168537786.66549748\/v1","type":"posted-content","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T12:31:10Z","timestamp":1685363470000},"source":"Crossref","is-referenced-by-count":0,"title":["Advanced Cell Technologies: Making Protein, Cell, and Gene Therapies a Reality"],"prefix":"10.22541","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1445-3556","authenticated-orcid":false,"given":"Paula","family":"Alves","sequence":"first","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnologica"}]},{"given":"Isabelle","family":"Geada","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Whiting School of Engineering"}]},{"given":"Antonio","family":"Roldao","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnologica"}]},{"given":"Michael","family":"Betenbaugh","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Whiting School of Engineering"}]}],"member":"311","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.authorea.com\/doi\/pdf\/10.22541\/au.168537786.66549748\/v1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:18:24Z","timestamp":1778674704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.authorea.com\/doi\/full\/10.22541\/au.168537786.66549748\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22541\/au.168537786.66549748\/v1","relation":{},"subject":[],"published":{"date-parts":[[2023,5,29]]},"subtype":"preprint"}}