{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:21:22Z","timestamp":1778674882196,"version":"3.51.4"},"posted":{"date-parts":[[2023,10,3]]},"reference-count":0,"publisher":"Wiley","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                  The aim of this study was to characterize the genetic diversity and drug\nresistance profiles of people with HIV-1 failing ART in Cape Verde (CV).\nThis cross- sectional study was conducted between January 2019 and\nDecember 2021 in 24 health centres on the islands of Santiago and S\u00e3o\nVicente. The HIV-1\n                  <jats:italic toggle=\"yes\">pol<\/jats:italic>\n                  gene was sequenced in individuals with a\ndetectable viral load (VL). Phylogenetic analysis was used to determine\nHIV-1 genetic diversity. Drug resistance mutation patterns and\nresistance phenotypes were estimated using the Stanford algorithm. VL\nwas detected in 73 of 252 (29%) enrolled participants and sequencing\ndata were produced for 58 (79%) participants. CRF02_AG strains\npredominated (46.5%), followed by subtype G (22.4%). Most patients\n(80%) had mutations conferring resistance to non-nucleoside reverse\ntranscriptase inhibitors (NNRTIs) (67%), nucleoside reverse\ntranscriptase inhibitors (55%), integrase inhibitors (10%) and\/or\nprotease inhibitors (7%) used in CV, a significant increase compared to\na study conducted in 2010-2011. The most common mutations were M184V\/I\n(43%), K103N\/S (36%) and G190A\/S (19%). NNRTI resistance was\nassociated with younger age and exposure to two or more drug regimens.\nThese results provide valuable information to guide appropriate\ntreatment for people failing antiretroviral therapy in CV.\n                <\/jats:p>","DOI":"10.22541\/au.169631469.96124050\/v1","type":"posted-content","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:31:40Z","timestamp":1696300300000},"source":"Crossref","is-referenced-by-count":0,"title":["HIV-1 drug resistance and genetic diversity in people with HIV-1 in Cape Verde, 2019-2021"],"prefix":"10.22541","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0176-5585","authenticated-orcid":false,"given":"Nuno","family":"Taveira","sequence":"first","affiliation":[{"name":"Universidade de Lisboa Instituto de Investigacao do Medicamento"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-6715","authenticated-orcid":false,"given":"Paloma","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa Instituto de Investigacao do Medicamento"}]},{"given":"Jorge","family":"Barreto","sequence":"additional","affiliation":[{"name":"Ministerio da Saude da Republica de Cabo Verde"}]},{"given":"Menilita","family":"Santos","sequence":"additional","affiliation":[{"name":"Ministerio da Saude da Republica de Cabo Verde"}]},{"given":"Silvania","family":"Leal","sequence":"additional","affiliation":[{"name":"Ministerio da Saude da Republica de Cabo Verde"}]},{"given":"Jos\u00e9","family":"Marcelino","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa Instituto de Investigacao do Medicamento"}]},{"given":"Ana","family":"Abecasis","sequence":"additional","affiliation":[{"name":"Universidade Nova de Lisboa Saude Global e Medicina Tropical"}]},{"given":"Claudia","family":"Palladino","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa Instituto de Investigacao do Medicamento"}]}],"member":"311","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/www.authorea.com\/doi\/pdf\/10.22541\/au.169631469.96124050\/v1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:53:49Z","timestamp":1778673229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.authorea.com\/doi\/full\/10.22541\/au.169631469.96124050\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22541\/au.169631469.96124050\/v1","relation":{},"subject":[],"published":{"date-parts":[[2023,10,3]]},"subtype":"preprint"}}