{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Authorea Inc."}],"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:42:56Z","timestamp":1748968976702,"version":"3.41.0"},"posted":{"date-parts":[[2024,4,15]]},"group-title":"Preprints","reference-count":0,"publisher":"Wiley","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,4,15]]},"abstract":"<jats:p id=\"p1\">To assess whether SARS-CoV-2 infection induces changes in the urinary\nvolatilomic fingerprint suitable for non-invasive COVID-19 diagnosis and\nmanagement, urine samples from SARS-CoV-2 infected patients (62),\nrecovered COVID-19 patients (30), and non-infected individuals (41),\nwere analysed using solid-phase microextraction technique in headspace\nmode, combined with gas chromatography hyphenated with mass spectrometry\n(HS-SPME\/GC-MS). A total of 101 volatile organic metabolites (VOMs) from\n13 chemical families were characterized, with terpenes, phenolic\ncompounds, norisoprenoids, and ketones being the most represented\ngroups. Overall, the levels of terpenes and phenolic compounds decreased\nin the control group, whereas those of norisoprenoids and ketones\nincreased significantly. In turn, a remarkable increase was noticed in\nnorisoprenoids and ketones and a milder increase in alcohols, furanic,\nand sulfur compounds in the recovery group than in the COVID group.\nMultivariate statistical analysis identified sets of VOMs that could\nconstitute the signatures of COVID-19 development and progression. These\nsignatures are composed of D-carvone,\n3-methoxy-5-(trifluoromethyl)aniline (MTA),\n1,1,6-trimethyl-dihydronaphthalene (TDN), 2-heptanone, and\n2,5,5,8a-tetramethyl-1,2,3,5,6,7,8,8-octahydro-1-naphthalenyl ester\nacetate (TONEA) for COVID-19 infection and nonanoic acid, \u03b1-terpinene,\n\u03b2-damascenone, \u03b1-isophorone, and trans-furan linalool for patients\nrecovering from the disease. The study reported in the current article\nprovides evidence that changes in the urinary volatilomic profile\ntriggered by SARS-CoV-2 infection constitute a promising and valuable\nscreening and\/or diagnostic and management tool for COVID-19 in clinical\nenvironment.<\/jats:p>","DOI":"10.22541\/au.171315894.49194485\/v1","type":"posted-content","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T05:29:11Z","timestamp":1713158951000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation the potential of urinary volatilomic patterns of patients infected with SARS-CoV-2 for COVID-19 diagnosis. An exploratory study"],"prefix":"10.22541","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-3151","authenticated-orcid":true,"given":"Jos\u00e9 S.","family":"C\u00e2mara","sequence":"first","affiliation":[{"name":"Universita Cattolica del Sacro Cuore - Campus di Roma"}]},{"given":"Giulia","family":"Riccio","sequence":"additional","affiliation":[{"name":"Universita Cattolica del Sacro Cuore - Campus di Roma"}]},{"given":"Joana","family":"Neto","sequence":"additional","affiliation":[{"name":"Universidade da Madeira Centro de Quimica da Madeira"}]},{"given":"Cristina V.","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Universidade da Madeira Centro de Quimica da Madeira"}]},{"given":"Cristina P.","family":"Ornelas","sequence":"additional","affiliation":[{"name":"Servico de Saude da Regiao Autonoma da Madeira"}]},{"given":"Viviana","family":"Greco","sequence":"additional","affiliation":[{"name":"Universita Cattolica del Sacro Cuore - Campus di Roma"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-5348","authenticated-orcid":true,"given":"Jorge A.M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade da Madeira Centro de Quimica da Madeira"}]},{"given":"Rosa","family":"Perestrelo","sequence":"additional","affiliation":[{"name":"Universidade da Madeira Centro de Quimica da Madeira"}]}],"member":"311","container-title":[],"original-title":[],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T05:29:11Z","timestamp":1713158951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.authorea.com\/users\/768720\/articles\/833462-evaluation-the-potential-of-urinary-volatilomic-patterns-of-patients-infected-with-sars-cov-2-for-covid-19-diagnosis-an-exploratory-study?commit=d1ca39651bf6e66ec3f8211aa415f13ade7731d1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22541\/au.171315894.49194485\/v1","relation":{},"subject":[],"published":{"date-parts":[[2024,4,15]]},"subtype":"preprint"}}