{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:24:56Z","timestamp":1768645496396,"version":"3.49.0"},"reference-count":14,"publisher":"Grigore T. Popa University of Medicine and Pharmacy","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Clin Cases"],"published-print":{"date-parts":[[2022,12,17]]},"abstract":"<jats:p>Juvenile Xanthogranuloma (XG) is a rare disorder that belongs to the heterogeneous group of histiocytic neoplasms, characterized by a clonal expansion of non-Langerhans cell histiocytes that share a dermal macrophage phenotype. Although the head and neck region is the most common reported site of involvement by the Juvenile Xanthogranuloma family, laryngeal localization is extremely rare. We report a unique case of Adult Onset Xanthogranuloma with subglottic localization, presenting as a solitary laryngeal mass without other systemic or cutaneous lesions. A review of the previously described cases of laryngeal Xanthogranuloma has been performed, highlighting 7 cases of Juvenile Xanthogranuloma and only 3 cases of Adult Onset Xanthogranuloma. Despite the extreme rarity of laryngeal localization of XG, this histiocytic neoplasm should be considered as a differential diagnosis for laryngeal masses causing airway obstruction, even in the absence of other concomitant manifestations.<\/jats:p>","DOI":"10.22551\/2022.37.0904.10221","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T12:35:53Z","timestamp":1671626153000},"page":"145-149","source":"Crossref","is-referenced-by-count":3,"title":["Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature"],"prefix":"10.22551","volume":"9","author":[{"name":"Department of Otorhinolaryngology, University of Rome \u201cTor Vergata\u201d, Rome, Italy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Velletrani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Francavilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology, University of Rome \u201cTor Vergata\u201d, Rome, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Rosati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Otorhinolaryngology, University of Rome \u201cTor Vergata\u201d, Rome, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9837","published-online":{"date-parts":[[2022,12,17]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"1. 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Am J Otolaryngol. 2016;37(2):112-5.","journal-title":"Am J Otolaryngol"},{"issue":"12","key":"ref6","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.jdcr.2019.09.018","article-title":"A case of generalized xanthogranuloma with systemic involvement","volume":"5","author":"Yoon","year":"2019","unstructured":"7. Yoon D, Jang D, Byun HJ, Park CS, Park JH, Lee JH, et al. A case of generalized xanthogranuloma with systemic involvement. JAAD Case Rep. 2019;5(12):1097-100.","journal-title":"JAAD Case Rep"},{"issue":"6","key":"ref7","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s13312-022-2543-0","article-title":"Juvenile Xanthogranuloma of Subglottis: Rare, Recurrent and Refractory","volume":"59","author":"Verma","year":"2022","unstructured":"8. Verma C, Taneja K, Mahajan A. Juvenile Xanthogranuloma of Subglottis: Rare, Recurrent and Refractory. 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