{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:39:23Z","timestamp":1776379163488,"version":"3.51.2"},"reference-count":16,"publisher":"Grigore T. Popa University of Medicine and Pharmacy","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Clin Cases"],"published-print":{"date-parts":[[2022,12,17]]},"abstract":"<jats:p>The global COVID-19 vaccination had an undeniable influence on the pandemic management, despite of having reported rare but life-threatening side-effects of vaccines. Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare autoimmune complication determined by thrombocytopenia and thrombosis propensity in the circulatory system. The activation of antibodies against platelet factor-4 (PF-4) which mimics the heparin-induced thrombocytopenia (HIT) characteristic is the main known pathogenicity of the disease. Herein, we reported a case of VITT in a middle-aged woman with no previous history of thrombophilia or other medical conditions who presented with thrombosis of the left superficial femoral artery 3-days after receiving the second dose of inactivated BBIBP-CorV (Sinopharm) vaccine. The patient underwent bypass vascular surgery and received none-heparin anticoagulation consistent with high-dose intravenous immunoglobin. Eight days after the discharge, she was subsequently referred to our center with the presentation of sub-massive pulmonary thromboembolism in spite of receiving the prophylactic anticoagulants during follow-up period. Details on side-effects of COVID-19 vaccines, specifically the inactivated ones are yet to be fully ascertained. Clinicians should consider the history of COVID-19 vaccines in thromboembolism patients who do not have well-acknowledged risk factors. Further studies about the necessity of prophylactic anticoagulants and clinical judgment for receiving other vaccines in such patients are required.<\/jats:p>","DOI":"10.22551\/2022.37.0904.10222","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T07:35:53Z","timestamp":1671608153000},"page":"150-153","source":"Crossref","is-referenced-by-count":4,"title":["Lower limb arterial thrombosis followed by sub-massive pulmonary thromboembolism after Sinopharm BBIBP-CorV COVID-19 vaccination"],"prefix":"10.22551","volume":"9","author":[{"name":"Abadan University of Medical Sciences, Abadan, Iran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamidreza","family":"Zaheri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arda","family":"Kiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siamak","family":"Afaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Prevention of Metabolic Disorders Research Center, Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9837","published-online":{"date-parts":[[2022,12,17]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"1. 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Deterioration of vaccine\u2010induced immune thrombotic thrombocytopenia treated by heparin and platelet transfusion: Insight from functional cytometry and serotonin release assay. Res Pract Thromb Haemost. 2021; 5(6):e12572. doi: 10.1002\/rth2.12572.","DOI":"10.1002\/rth2.12572"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Lentz SR. Cooling down VITT with IVIG. Blood. 2021; 138(11):921-922. doi: 10.1182\/blood.2021012819.","DOI":"10.1182\/blood.2021012819"},{"key":"ref15","unstructured":"\""}],"container-title":["Archive of Clinical Cases"],"original-title":[],"deposited":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T01:04:49Z","timestamp":1677719089000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.clinicalcases.eu\/index.php\/acc\/article\/view\/801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,17]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12,17]]},"published-print":{"date-parts":[[2022,12,17]]}},"URL":"https:\/\/doi.org\/10.22551\/2022.37.0904.10222","relation":{},"ISSN":["2360-6975","2360-6975"],"issn-type":[{"value":"2360-6975","type":"print"},{"value":"2360-6975","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,17]]}}}