{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:08:26Z","timestamp":1764133706093},"reference-count":8,"publisher":"Grigore T. Popa University of Medicine and Pharmacy","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Clin Cases"],"abstract":"<jats:p>Small fiber neuropathy (SFN) has not been reported after the third dose of BNT162b2 in a previously healthy vaccinee. A 44-year-old previously healthy female developed pain and sensory disturbances in varying locations after the third BNT162b2 dose. Additionally, she developed recurrent tinnitus, headaches, arthralgia, neck stiffness, and motor dysfunction. A skin biopsy five months after symptom onset revealed normal intra-epidermal nerve fiber density (IENFD) but reduced sweat gland nerve fiber density. She is intended for a first series of intravenous immunoglobulins. SARS-CoV-2 vaccinations may be complicated by SFN; the diagnosis SARS-CoV-2 vaccination SFN may be delayed; IENFD may be normal, but sweat gland nerve fiber density may document SFN; and full recovery after SFN cannot always be achieved quickly.<\/jats:p>","DOI":"10.22551\/2023.41.1004.10264","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T10:46:26Z","timestamp":1704797186000},"page":"153-156","source":"Crossref","is-referenced-by-count":2,"title":["Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot"],"prefix":"10.22551","volume":"10","author":[{"name":"Neurology Neurophysiology Center, Vienna, Austria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Finsterer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9837","published-online":{"date-parts":[[2023,12,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"1. Finsterer J, Scorza FA. Small fiber neuropathy. Acta Neurol Scand. 2022;145(5):493-503. doi: 10.1111\/ane.13591. PMID: 35130356.","DOI":"10.1111\/ane.13591"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Egenolf N, Zu Altenschildesche CM, Kre\u00df L, et al. Diagnosing small fiber neuropathy in clinical practice: a deep phenotyping study. Ther Adv Neurol Disord. 2021;14:17562864211004318. doi: 10.1177\/17562864211004318. Erratum in: Ther Adv Neurol Disord. 2021;14:17562864211036650. PMID: 34335876; PMCID: PMC8283814.","DOI":"10.1177\/17562864211004318"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Khokhar F, Khan A, Hussain Z, Yu J. Small Fiber Neuropathy Associated With the Moderna SARS-CoV-2 Vaccine. Cureus. 2022;14(6):e25969. doi: 10.7759\/cureus.25969. PMID: 35812635; PMCID: PMC9259076.","DOI":"10.7759\/cureus.25969"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Safavi F, Gustafson L, Walitt B, et al. Neuropathic symptoms with SARS-CoV-2 vaccination. medRxiv [Preprint]. 2022:2022.05.16.22274439. doi: 10.1101\/2022.05.16.22274439. PMID: 35611338; PMCID: PMC9128783.","DOI":"10.1101\/2022.05.16.22274439"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Watad A, De Marco G, Mahajna H, et al. Immune-Mediated Disease Flares or New-Onset Disease in 27 Subjects Following mRNA\/DNA SARS-CoV-2 Vaccination. Vaccines (Basel). 2021;9(5):435. doi: 10.3390\/vaccines9050435. PMID: 33946748; PMCID: PMC8146571.","DOI":"10.3390\/vaccines9050435"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Abbott MG, Allawi Z, Hofer M, et al. Acute small fiber neuropathy after Oxford-AstraZeneca ChAdOx1-S vaccination: A report of three cases and review of the literature. J Peripher Nerv Syst. 2022;27(4):325-329. doi: 10.1111\/jns.12509. PMID: 35962630; PMCID: PMC9538519.","DOI":"10.1111\/jns.12509"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Schelke MW, Barcavage S, Lampshire E, Brannagan TH 3rd. Post-COVID-19 vaccine small-fiber neuropathy and tinnitus treated with plasma exchange. Muscle Nerve. 2022;66(4):E21-E23. doi: 10.1002\/mus.27696. PMID: 35934893; PMCID: PMC9537871.","DOI":"10.1002\/mus.27696"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Waheed W, Carey ME, Tandan SR, Tandan R. Post COVID-19 vaccine small fiber neuropathy. Muscle Nerve. 2021;64(1):E1-E2. doi: 10.1002\/mus.27251. PMID: 33851437; PMCID: PMC8250971. \"","DOI":"10.1002\/mus.27251"}],"container-title":["Archive of Clinical Cases"],"original-title":[],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T10:50:09Z","timestamp":1704797409000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.clinicalcases.eu\/index.php\/acc\/article\/view\/1015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,30]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,12,30]]}},"URL":"https:\/\/doi.org\/10.22551\/2023.41.1004.10264","relation":{},"ISSN":["2360-6975","2360-6975"],"issn-type":[{"type":"print","value":"2360-6975"},{"type":"electronic","value":"2360-6975"}],"subject":[],"published":{"date-parts":[[2023,12,30]]}}}