{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:04:12Z","timestamp":1761563052302,"version":"3.37.3"},"reference-count":11,"publisher":"Grigore T. Popa University of Medicine and Pharmacy","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Clin Cases"],"published-print":{"date-parts":[[2024,5,25]]},"abstract":"<jats:p>Infection with SARS-CoV-2 has been shown to predispose to thromboembolic events. The risk of such thromboses further increases in those with underlying inherited or acquired prothrombotic states. The authors present a 30-year-old lady who developed acute abdominal pain, three days after recovery from a mild COVID-19 infection. She was also using oral contraceptive pills. Laboratory investigations revealed elevated inflammatory markers, and a contrast-enhanced abdominal CT scan demonstrated portal vein thrombosis (PVT). Due to the unusual site of thrombosis, a thrombophilia screen was performed, which detected a heterozygous Factor V Leiden mutation (FVL). Thus, her PVT was attributed three simultaneous risk factors, namely COVID-19 infection, OCP use and FVL mutation. She was initiated on anti-coagulation, with which she improved significantly. In patients presenting with thromboses at uncommon sites, investigation for evidence of recent Covid-19 infection and screening for inherited and acquired thrombophilia should be considered, while discontinuing any offending medications.<\/jats:p>","DOI":"10.22551\/2024.42.1101.10280","type":"journal-article","created":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T09:00:18Z","timestamp":1716714018000},"page":"16-18","source":"Crossref","is-referenced-by-count":1,"title":["Triple whammy in a patient with portal vein thrombosis"],"prefix":"10.22551","volume":"11","author":[{"name":"Derriford Hospital, University Hospitals Plymouth NHS foundation Trust, Plymouth, UK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-3827","authenticated-orcid":false,"given":"Elamein","family":"Yousif","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elamin","family":"Dahawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Al-Ahli Hospital, Doha, Qatar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-7752","authenticated-orcid":false,"given":"Sarah","family":"Premraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"East Suffolk and North Essex NHS Foundation Trust, Colchester, Essex, UK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9837","published-online":{"date-parts":[[2024,5,25]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"1. Salabei JK, Fishman TJ, Asnake ZT, Ali A, Iyer UG. COVID-19 Coagulopathy: Current knowledge and guidelines on anticoagulation. Heart Lung. 2021 Mar-Apr;50(2):357-360. doi: 10.1016\/j.hrtlng.2021.01.011. PMID: 33524866; PMCID: PMC7816593.","DOI":"10.1016\/j.hrtlng.2021.01.011"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Clavijo MM, Vicente Reparaz MLA, Ruiz JI, et al. Mild COVID-19 Illness as a Risk Factor for Venous Thromboembolism. Cureus. 2021 Sep 24;13(9):e18236. doi: 10.7759\/cureus.18236. PMID: 34722035; PMCID: PMC8544806.","DOI":"10.7759\/cureus.18236"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Ho FK, Man KKC, Toshner M, et al. Thromboembolic Risk in Hospitalized and Nonhospitalized COVID-19 Patients: A Self-Controlled Case Series Analysis of a Nationwide Cohort. Mayo Clin Proc. 2021 Oct;96(10):2587-2597. doi: 10.1016\/j.mayocp.2021.07.002. PMID: 34607634; PMCID: PMC8282478.","DOI":"10.1016\/j.mayocp.2021.07.002"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. La Mura V, Artoni A, Martinelli I, et al. Acute Portal Vein Thrombosis in SARS-CoV-2 Infection: A Case Report. Am J Gastroenterol. 2020 Jul 1;115(7):1140-1142. doi: 10.14309\/ajg.0000000000000711. PMID: 32618673; PMCID: PMC7273956.","DOI":"10.14309\/ajg.0000000000000711"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Borazjani R, Seraj SR, Fallahi MJ, Rahmanian Z. Acute portal vein thrombosis secondary to COVID-19: a case report. BMC Gastroenterol. 2020 Nov 19;20(1):386. doi: 10.1186\/s12876-020-01518-2. PMID: 33213374; PMCID: PMC7675382.","DOI":"10.1186\/s12876-020-01518-2"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Sharma N, Shukla R, Kumar K, et al. Portal Vein Thrombosis-a Rare Complication of SARS-CoV-2 Infection. SN Compr Clin Med. 2021;3(6):1416-1419. doi: 10.1007\/s42399-021-00877-5. PMID: 33842842; PMCID: PMC8025736.","DOI":"10.1007\/s42399-021-00877-5"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Appenzeller F, Schmehl J, Gawaz M, M\u00fcller I. Extensive Thromboembolism in a Young Male with Asymptomatic COVID-19 Infection and Heterozygous Factor V Leiden Mutation. Hamostaseologie. 2021 Oct;41(5):400-402. doi: 10.1055\/a-1554-6390. PMID: 34492713.","DOI":"10.1055\/a-1554-6390"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Stefely JA, Christensen BB, Gogakos T, et al. Marked factor V activity elevation in severe COVID-19 is associated with venous thromboembolism. Am J Hematol. 2020 Dec;95(12):1522-1530. doi: 10.1002\/ajh.25979. PMID: 32833259; PMCID: PMC7461432.","DOI":"10.1002\/ajh.25979"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Stevens H, Canovas R, Peter K, et al. Inherited Thrombophilias Are Associated with an Increased Risk of COVID-19 Associated Venous Thromboembolism: A Prospective Population-Based Cohort Study Blood. 2021 Nov;138(19):3214-3214. PMCID: PMC8701572.","DOI":"10.1182\/blood-2021-149841"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Denninger MH, Cha\u00eft Y, Casadevall N, et al. Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors. Hepatology. 2000 Mar;31(3):587-91. doi: 10.1002\/hep.510310307. PMID: 10706547.","DOI":"10.1002\/hep.510310307"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Arachchillage DJ, Mackillop L, Chandratheva A, et al. Thrombophilia testing: A British Society for Haematology guideline. Br J Haematol. 2022 Aug;198(3):443-458. doi: 10.1111\/bjh.18239. PMID: 35645034; PMCID: PMC9542828. \"","DOI":"10.1111\/bjh.18239"}],"container-title":["Archive of Clinical Cases"],"original-title":[],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T09:02:04Z","timestamp":1716714124000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalcases.eu\/index.php\/acc\/article\/view\/1059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,25]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,5,25]]},"published-print":{"date-parts":[[2024,5,25]]}},"URL":"https:\/\/doi.org\/10.22551\/2024.42.1101.10280","relation":{},"ISSN":["2360-6975","2360-6975"],"issn-type":[{"type":"print","value":"2360-6975"},{"type":"electronic","value":"2360-6975"}],"subject":[],"published":{"date-parts":[[2024,5,25]]}}}