{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T04:02:25Z","timestamp":1748491345947,"version":"3.41.0"},"reference-count":16,"publisher":"Grigore T. Popa University of Medicine and Pharmacy","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Clin Cases"],"abstract":"<jats:p>The nephrotic syndrome (NS) is caused by increased glomerular permeability. We report a case of NS in a 3-year-old girl, complicated with central nervous system venous thrombosis. Physical examination revealed anasarca (edema, pleurisy, and ascites), intensely foaming urine. The lab tests showed severe, non-selective proteinuria, marked hypoproteinemia, dyslipidemia; also associated with abnormal thyroid panel due to urinary binding protein loss. Once the diagnosis was established and pathogen-specific treatment was started, the clinical and paraclinical evolution were favorable. A prolonged right body seizure was the onset symptom of cerebral venous infarction due to sagittal sinus thrombosis. Short- and long-term outcomes of the thrombosis can be severe, so anticoagulant therapy was promptly initiated.<\/jats:p>","DOI":"10.22551\/2025.46.1201.10313","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T08:35:21Z","timestamp":1744792521000},"page":"54-58","source":"Crossref","is-referenced-by-count":0,"title":["Sagittal sinus thrombosis - rare complication of nephrotic syndrome in a young child"],"prefix":"10.22551","volume":"12","author":[{"name":"Department of Pediatrics, \u201cGrigore Alexandrescu\u201d Emergency Children\u2019s Hospital, Bucharest, Romania","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalin Ionut","family":"Lupu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca Maria","family":"Vlad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Pediatrics, \u201cGrigore Alexandrescu\u201d Emergency Children\u2019s Hospital, Bucharest, Romania; \u201cCarol Davila\u201d University of Medicine and Pharmacy, Bucharest, Romania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9837","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"1. 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Relationship between platelet aggregation, thromboxane synthesis and albumin concentration in nephrotic syndrome. Br J Haematol. 1982 Sep;52(1):69-77. doi: 10.1111\/j.1365-2141.1982.tb03862.x. PMID: 6810912.","DOI":"10.1111\/j.1365-2141.1982.tb03862.x"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Hogg RJ, Portman RJ, Milliner D, et al. Evaluation and management of proteinuria and nephrotic syndrome in children: recommendations from a pediatric nephrology panel established at the National Kidney Foundation conference on proteinuria, albuminuria, risk, assessment, detection, and elimination (PARADE). Pediatrics. 2000 Jun;105(6):1242-9. doi: 10.1542\/peds.105.6.1242. PMID: 10835064.","DOI":"10.1542\/peds.105.6.1242"},{"key":"ref5","unstructured":"6. Niaudet P. Steriod-sensitive idiopathic nephrotic syndrome in children. In: Pediatric Nephrology, 5th ed, Avner ED, Harmon WE, Niaudet P (Eds), Lippincott Williams & Wilkins, Philadelphia 2004. p.549."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Llach F. Hypercoagulability, renal vein thrombosis, and other thrombotic complications of nephrotic syndrome. Kidney Int. 1985 Sep;28(3):429-39. doi: 10.1038\/ki.1985.149. PMID: 3906225.","DOI":"10.1038\/ki.1985.149"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Rabelink TJ, Zwaginga JJ, Koomans HA, Sixma JJ. Thrombosis and hemostasis in renal disease. Kidney Int. 1994 Aug;46(2):287-96. doi: 10.1038\/ki.1994.274. PMID: 7967339.","DOI":"10.1038\/ki.1994.274"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Diaz JM, Schiffman JS, Urban ES, Maccario M. Superior sagittal sinus thrombosis and pulmonary embolism: a syndrome rediscovered. Acta Neurol Scand. 1992 Oct;86(4):390-6. doi: 10.1111\/j.1600-0404.1992.tb05106.x. PMID: 1455986.","DOI":"10.1111\/j.1600-0404.1992.tb05106.x"},{"key":"ref9","unstructured":"10. Schobess R, D\u00fcring C, Bidlingmaier C, et al. Long-term safety and efficacy data on childhood venous thrombosis treated with a low molecular weight heparin: an open-label pilot study of once-daily versus twice-daily enoxaparin administration. Haematologica. 2006 Dec;91(12):1701-4. PMID: 17145610."},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Int. 2021 Oct;100(4S):S1-S276. doi: 10.1016\/j.kint.2021.05.021. PMID: 34556256.","DOI":"10.1016\/j.kint.2021.05.021"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Monagle P, Chan AKC, Goldenberg NA, et al. Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e737S-e801S. doi: 10.1378\/chest.11-2308. Erratum in: Chest. 2014 Dec;146(6):1694. Dosage error in article text. Erratum in: Chest. 2014 Nov;146(5):1422. PMID: 22315277; PMCID: PMC3278066.","DOI":"10.1378\/chest.14-2167"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. Ferro JM, Bousser MG, Canh\u00e3o P, et al. European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - endorsed by the European Academy of Neurology. Eur J Neurol. 2017 Oct;24(10):1203-1213. doi: 10.1111\/ene.13381. PMID: 28833980.","DOI":"10.1111\/ene.13381"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Ferro JM, Canh\u00e3o P, Bousser MG, et al. Early seizures in cerebral vein and dural sinus thrombosis: risk factors and role of antiepileptics. Stroke. 2008 Apr;39(4):1152-8. doi: 10.1161\/STROKEAHA.107.487363. PMID: 18309177.","DOI":"10.1161\/STROKEAHA.107.487363"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Ueda N, Kawaguchi S, Niinomi Y, et al. Effect of corticosteroids on coagulation factors in children with nephrotic syndrome. Pediatr Nephrol. 1987 Jul;1(3):286-9. doi: 10.1007\/BF00849225. PMID: 3153290.","DOI":"10.1007\/BF00849225"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Canh\u00e3o P, Ferro JM, Lindgren AG, et al. Causes and predictors of death in cerebral venous thrombosis. Stroke. 2005 Aug;36(8):1720-5. doi: 10.1161\/01.STR.0000173152.84438.1c. 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