{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:59:34Z","timestamp":1780991974857,"version":"3.54.1"},"reference-count":20,"publisher":"Grigore T. Popa University of Medicine and Pharmacy","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Clin Cases"],"abstract":"<jats:p>Melkersson-Rosenthal syndrome (MRS) is a rare and often challenging condition of unknown etiology, typically defined by a clinical triad of peripheral facial nerve palsy, recurrent orofacial edema, and fissured tongue. Its variable presentation and overlap with allergic reactions, mast cell-mediated disorders, and drug hypersensitivity reactions can delay diagnosis and appropriate management. We report the case of a 43-year-old man with a personal long-standing history of recurrent hemifacial and lip swelling associated with facial nerve palsy and a plicated tongue, fulfilling the complete clinical triad of MRS. Extensive laboratory, immunological, infectious, and allergological investigations ruled out alternative diagnoses, including hereditary angioedema and drug hypersensitivity. Histopathological examination of a lip biopsy did not reveal granulomatous inflammation. The disease was refractory to multiple standard therapies, including antihistamines, corticosteroids, epinephrine, antibiotics, and immunomodulatory agents. Administration of fresh frozen plasma at a dose of 10 ml\/kg resulted in a rapid and marked clinical improvement within 6 hours. This case highlights a rare complete presentation of MRS and underscores the challenges in diagnosis and management. The favorable response to fresh frozen plasma suggests a potential therapeutic option in refractory cases; however, further studies are required to clarify its role and mechanism of action in Melkersson-Rosenthal syndrome.<\/jats:p>","DOI":"10.22551\/2026.51.1302.10337","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:26:10Z","timestamp":1780989970000},"page":"26-29","source":"Crossref","is-referenced-by-count":0,"title":["Melkersson-Rosenthal syndrome in an allergic patient successfully treated with fresh frozen plasma"],"prefix":"10.22551","volume":"13","author":[{"name":"Department of Immunology, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania; Department of Allergy and Clinical Immunology, Sf. Spiridon Clinical County Hospital, Iasi, Romania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6590-1889","authenticated-orcid":false,"given":"Delia","family":"Urdea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-2030","authenticated-orcid":false,"given":"Florentina","family":"Severin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Otorhinolaryngology, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3978-5103","authenticated-orcid":false,"given":"Victor V.","family":"Costan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Oral and Maxillofacial Surgery, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"9837","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"\"[1] Wang S, Wang H, Shi X, et al. A case of Melkersson-Rosenthal syndrome with endocrine disorders: Extraordinary efficiency of hydroxychloroquine and mechanism hypothesis. Eur J Neurol. 2021 Mar;28(3):928-933. doi: 10.1111\/ene.14615. 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