{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T07:15:47Z","timestamp":1717658147564},"reference-count":0,"publisher":"National Library of Serbia","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ComSIS","COMPUT SCI INF SYST","COMPUT SCI INFORM SY","COMPUTER SCI INFORM","COMSIS J"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>We address the problem of the annotation of CpG islands (CGIs) clusters in the human genome. Upon analyzing gene content within CGIs clusters, piRNA, tRNA, and miRNA-encoding genes were found as well as CpG-rich homeobox genes reported previously. Chromosome-wide CGI density is positively correlated with replication timing, confirming that CGIs may serve as open chromatin markers. Early embryonic stage expressed KRAB-ZNF genes abundant at chromosome 19 were found to be interlinked with CGI clusters. We detected that a number of long CGIs and CGI clusters are, in fact, tandem copies with multiple annotated macrosatellites and paralogous genes. This finding implies that tandem expansion of CGIs may serve as a substrate for nonhomologous recombination events.<\/jats:p>","DOI":"10.2298\/csis170523004b","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T10:29:53Z","timestamp":1529317793000},"page":"473-485","source":"Crossref","is-referenced-by-count":2,"title":["CpG islands\u2019 clustering uncovers early development genes in the human genome"],"prefix":"10.2298","volume":"15","author":[{"suffix":"N.","given":"Vladimir","family":"Babenko","sequence":"first","affiliation":[{"name":"Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia + Novosibirsk State University, Novosibirsk, Russia + The A.O. Kovalevsky Institute of Marine Biological Research of RAS, Sevastopol, Russia"}]},{"suffix":"G.","given":"Anton","family":"Bogomolov","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia + Novosibirsk State University, Novosibirsk, Russia"}]},{"suffix":"O.","given":"Roman","family":"Babenko","sequence":"additional","affiliation":[{"name":"Novosibirsk State University, Novosibirsk, Russia"}]},{"suffix":"R.","given":"Elvira","family":"Galieva","sequence":"additional","affiliation":[{"name":"Novosibirsk State University, Novosibirsk, Russia"}]},{"suffix":"L.","given":"Yuriy","family":"Orlov","sequence":"additional","affiliation":[{"name":"Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia + Novosibirsk State University, Novosibirsk, Russia + The A.O. Kovalevsky Institute of Marine Biological Research of RAS, Sevastopol, Russia"}]}],"member":"1078","container-title":["Computer Science and Information Systems"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T08:33:25Z","timestamp":1685349205000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=1820-02141800004B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.2298\/csis170523004b","relation":{},"ISSN":["1820-0214","2406-1018"],"issn-type":[{"value":"1820-0214","type":"print"},{"value":"2406-1018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}