{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:57:34Z","timestamp":1747209454309,"version":"3.40.5"},"reference-count":7,"publisher":"National Library of Serbia","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Introduction Diabetic nephropathy is the leading cause of hypertension in type 1 diabetes. Microalbuminuria is usually the first manifestation of renal disease and antedate hypertension. The aim of this study was to investigate relationships between glycemic control, hypertension and microalbuminuria in type 1 diabetics. Material and methods We studied 27 type 1 diabetics, 18 male and 9 female, aged 18-50 years, with a duration of diabetes &lt;20 years. Glycemic control was assessed using glycosylated hemoglobin (HbAlc) measurements, fructosamine and lipid analysis. 24-h urinary albumin excretion rate was evaluated by radioimmunoassay. Patients with persistent urinary albumin excretion rate 30-300 nig\/24 h were defined as microalbuminuric (Group A -41% patients) and lower than that, as normoalbuminuric (Group B -59%). We examined them twice: first in poor glycemic control and then in good glycemic control. Results We found significant differences (Student's t-test) between groups in regard to microalbuminuria (p&lt;0.01), diabetes duration (p&lt;0.05), systolic blood pressure (BP) and diastolic BP (p&lt;0.05). Systolic BP (p&lt;0.01), diastolic BP (p&lt;0.01) and microalbuminuria (p=0,05) positively correlated (Spearman's rho) with poor glycemic control in Group A. In both groups there was a significant improvement in glycemic control and regression in systolic and diastolic BP (p&lt;0.01), but only Group B showed significant reduction in urinary albumin excretion rate (p&lt;0.0l). Discussion and conclusion In this study, type 1 diabetics showed regression in systolic and diastolic hypertension with improvements of glycemic control regardless of presence of microalbuminuria, but only normoalbuminuric showed significant reduction in urinary albumin excretion rate.<\/jats:p>","DOI":"10.2298\/mpns0512572v","type":"journal-article","created":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T09:19:46Z","timestamp":1153473586000},"page":"572-575","source":"Crossref","is-referenced-by-count":0,"title":["Effect of glycemic control on microalbuminuria and arterial blood pressure in patients with type 1 diabetes"],"prefix":"10.2298","volume":"58","author":[{"given":"Olga","family":"Vasovic","sequence":"first","affiliation":[{"name":"Gradski zavod za gerontologiju, ku\u0107no le\u010denje i negu, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslava","family":"Zamaklar","sequence":"additional","affiliation":[{"name":"Institut za endokrinologiju, dijabetes i bolesti metabolizma, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-1899","authenticated-orcid":false,"given":"Katarina","family":"Lalic","sequence":"additional","affiliation":[{"name":"Institut za endokrinologiju, dijabetes i bolesti metabolizma, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragoslav","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Interna klinika, Centar za gerijatriju, Klini\u010dko-bolni\u010dki centar 'Zvezdara', Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana","family":"Zikic","sequence":"additional","affiliation":[{"name":"Gradski zavod za gerontologiju, ku\u0107no le\u010denje i negu, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana","family":"Popovic","sequence":"additional","affiliation":[{"name":"Institut za endokrinologiju, dijabetes i bolesti metabolizma, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1572"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.6.1149"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1580"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.8.1329"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.4.421"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.3.651"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.3.803"}],"container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:19:44Z","timestamp":1685351984000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81050512572V"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":7,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns0512572v","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"type":"print","value":"0025-8105"},{"type":"electronic","value":"1820-7383"}],"subject":[],"published":{"date-parts":[[2005]]}}}