{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:57:43Z","timestamp":1747209463930,"version":"3.40.5"},"reference-count":6,"publisher":"National Library of Serbia","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Introduction. The frequency of occurrence of RhD alloimmunization, due to preventive protocols, is decreased in our country, but more often there are other antigens that emerge as a cause of hemolytic disease of fetus. The most prominent is Kell antigen, which promotes specific course of disease based on an innate pathogenetic mechanism. Anti- Kell antibody production is, just as in other atypical antibodies, provoked with transfusion of incompatible blood. Except for the immune-mediated hemolysis, anti - Kell antibodies can also inhibit the function of progenitor (erytroid and megakariocyte) cell lines. Case report. We present the case of G1P1 woman in whom a distinct fetal hydrops was sonographically detected in the 28th week of pregnancy. The results of immunological tests undoubtedly pointed to Kell immunization (anti - Kell antibody titer was more than 1:32), and antenatal tests for evaluation of fetal condition (Doppler ultrasound and CTG) clearly showed the severe form of hemolytic disease. We concluded that the fetus was in a hopeless, terminal stage of the disease, and then decided to terminate the pregnancy. Conclusion. The only clinical approach to a problem of Kell alloimunization is active one. Early cordocentesis is recommended as the optimal method for evaluation of fetal condition. The clinical outcome of the fetus will strictly depend on a timely intrauterine transfusion (IUT) procedure. Prophylaxis emerges as a crucial factor in prevention of Kell - alloimmunization. It is to be considered that all females in childhood and throughout the reproductive period should take only K1 - negative blood transfusion in order to decrease the incidence of Kell - alloimmunization.<\/jats:p>","DOI":"10.2298\/mpns0908369t","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T13:26:35Z","timestamp":1259069195000},"page":"369-372","source":"Crossref","is-referenced-by-count":0,"title":["Kell immunization: A case report"],"prefix":"10.2298","volume":"62","author":[{"given":"Marija","family":"Tasic","sequence":"first","affiliation":[{"name":"Klini\u010dki centar, Ginekolo\u0161ko-aku\u0161erska klinika, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar, Ginekolo\u0161ko-aku\u0161erska klinika, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar, Ginekolo\u0161ko-aku\u0161erska klinika, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Radovic-Janosevic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar, Ginekolo\u0161ko-aku\u0161erska klinika, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-297X","authenticated-orcid":false,"given":"Miljan","family":"Krstic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar, Institut za patologiju, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Antic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar, Ginekolo\u0161ko-aku\u0161erska klinika, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70161-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190290011949"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00491-8"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb13266.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803193381204"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00428-0"}],"container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:21:38Z","timestamp":1685352098000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81050908369T"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":6,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns0908369t","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"type":"print","value":"0025-8105"},{"type":"electronic","value":"1820-7383"}],"subject":[],"published":{"date-parts":[[2009]]}}}