{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:57:50Z","timestamp":1747209470230,"version":"3.40.5"},"reference-count":4,"publisher":"National Library of Serbia","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Introduction. Multifocal choroidopathy syndromes are a group of rare\n   disorders, which involve a primary pathologic process occurring at or near\n   the level of the retinal pigment epithelium, with or without choriocapillaris\n   involvement. The aetiology of multifocal choroidopathy syndrome is still\n   unknown. A case report. We present a case of multifocal choroidopathy\n   syndrome. A 54-year-old woman was referred to our department with blurred\n   vision on both eyes, mild ocular pain, accompanied by metamorphopsia,\n   floaters, scotomas and photopsia. The anterior segment examination showed\n   small to medium size keratic precipitates, posterior synechiae, and iris\n   atrophy. Mild to moderate aqueous inflammation with cells and flair was\n   present in the anterior chamber. The fundus examination showed multiple small\n   yellow-white spots, round-shaped changes located at the level of the retinal\n   pigment epithelium and choriocapillaris. According to the fluorescein\n   angiography the active lesions exhibited blockage of the early choroidal\n   fluorescence followed by late staining. The old inactive lesions corresponded\n   to the retinal pigment epithelium windows defects. The laboratory examination\n   showed high level of blood glucose, C reactive protein, cholesterol HDL, LDL,\n   triglycerides. According to the immunological examination the C3 component of\n   complement was lower (0.630), as well as the C4 component of complement\n   (0.158), and the immunological complex in blood was elevated (171). ELIZA\n   test on viral infection showed Citomegalo viruses IgG positive, Herpes\n   Simplex Virus IgG positive, Varichela Zoster Virus IgG positive. The results\n   of human leucocyte antigen typization were human leucocyte antigen A1:A2,\n   human leucocyte antigen A2:A24(9), human leucocyte antigen B1:B44(12), human\n   leucocyte antigen B2:B60(40), human leucocyte antigen C1:Cw3, human leucocyte\n   antigen C2:Cw5. The radiological examination of lungs, the Mantoux test,\n   Treponemal serology, Toxocara and Toxoplasma serology, magnetic resonance of\n   endocranium and orbit were also performed. The multiple viral infection,\n   which was detected in our patient with immunological abnormalities pointed to\n   an underlying autoimmune mechanism, possibly triggered by an infectious\n   agent, a virus.<\/jats:p>","DOI":"10.2298\/mpns1104219c","type":"journal-article","created":{"date-parts":[[2011,6,11]],"date-time":"2011-06-11T08:00:37Z","timestamp":1307779237000},"page":"219-222","source":"Crossref","is-referenced-by-count":0,"title":["Multifocal choroidopathy syndrome: A case report"],"prefix":"10.2298","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-9043","authenticated-orcid":false,"given":"Sonja","family":"Cekic","sequence":"first","affiliation":[{"name":"Klini\u010dki centar Ni\u0161, Klinika za o\u010dne bolesti, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3565-9994","authenticated-orcid":false,"given":"Gordana","family":"Stankovic-Babic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Ni\u0161, Klinika za o\u010dne bolesti, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Institut za anatomiju, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000310476"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1159\/000050820"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2004.00343.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00901-0"}],"container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:22:49Z","timestamp":1685352169000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81051104219C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":4,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns1104219c","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"type":"print","value":"0025-8105"},{"type":"electronic","value":"1820-7383"}],"subject":[],"published":{"date-parts":[[2011]]}}}