{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:06:41Z","timestamp":1685419601170},"reference-count":11,"publisher":"National Library of Serbia","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Introduction. Juvenile myasthenia is a chronic autoimmune neuromuscular\n   disease characterized by varying degrees of fluctuating, painless muscle\n   weakness and rapid fatigue of any muscles under voluntary control. Juvenile\n   myasthenia is a form of myasthenia appearing in adolescent age, representing\n   10% to 15% of all cases of myasthenia gravis. Juvenile myasthenia is\n   presented by a defect in the transmission of nerve impulses to muscles,\n   resulting from a breakdown in the normal communication between nerves and\n   muscles. In myasthenia, antibodies produced by the body?s own immune system\n   block, alter, or destroy the receptors for acetylcholine. Juvenile myasthenia\n   is neither directly inherited nor is it contagious. Signs and Symptoms. The\n   first noticeable symptoms may be eye muscle weakness, difficulty in\n   swallowing, or slurred speech. Juvenile myasthenia usually affects muscles\n   innervated by the cranial nerves (face, lips, tongue, neck and throat), but\n   it can affect any muscle group. Symptoms vary in type and severity with\n   typical periods of exacerbation interspersed with periods of remission. When\n   the muscles necessary for breathing are affected, a patient is said to be in\n   a myasthenic crisis, which is a life-threatening situation. Disease Outcome\n   and Treatment. Juvenile myasthenia produces sporadic but progressive weakness\n   and abnormal fatigability of striated (skeletal) muscles, exacerbated by\n   exercise and repeated movement, but improved by rest and anticholinesterase\n   drugs. Juvenile myasthenia follows an unpredictable course of recurring\n   exacerbations and periodic remissions. With current therapies, however, most\n   cases of juvenile myasthenia are not as serious as the name implies. Although\n   there is no known cure, drug treatment has improved prognosis and allows\n   patients to lead relatively normal lives, except during exacerbations.<\/jats:p>","DOI":"10.2298\/mpns1106295k","type":"journal-article","created":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T10:17:35Z","timestamp":1310984255000},"page":"295-298","source":"Crossref","is-referenced-by-count":1,"title":["Juvenile myasthenia"],"prefix":"10.2298","volume":"64","author":[{"given":"Marija","family":"Knezevic-Pogancev","sequence":"first","affiliation":[{"name":"Institut za zdravstvenu za\u0161titu dece i omladine Vojvodine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073808325651"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05186-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1981.tb33764.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-008-0158-y"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.157.4.399"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406233302507"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20854"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2298\/MPNS0910412V"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/BF01954388"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01476.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0810"}],"container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:22:52Z","timestamp":1685352172000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81051106295K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":11,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns1106295k","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"value":"0025-8105","type":"print"},{"value":"1820-7383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}