{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T03:56:25Z","timestamp":1767239785258},"reference-count":23,"publisher":"National Library of Serbia","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2011]]},"abstract":"Introduction. Juvenile myoclonic epilepsy is an idiopathic, hereditary form\n of epilepsy. Although juvenile myoclonic epilepsy is a well defined clinical\n syndrome, attempts at diagnosing it commonly fail. Etiopathogenesis. The\n exact cause of juvenile myoclonic epilepsy remains unknown. Clinical,\n morphological and metabolic data suggest a preferential role for frontal\n regions in this syndrome. Several major genes for juvenile myoclonic epilepsy\n have been identified, but these genes account for only a small proportions of\n juvenile myoclonic epilepsy cases, suggesting multifactorial or complex\n inheritance in most. Clinical Manifestations. Juvenile myoclonic epilepsy is\n characterized by the triad of myoclonic jerks on awakening (all patients),\n generalized tonic-clonic seizures (>90% of patients) and typical absences\n (about one third of patients). Seizures have an age-related onset, circadian\n distribution and are frequently precipitated by sleep deprivation, fatigue\n and alcohol intake. Intelligence is normal. Diagnosis. Juvenile myoclonic\n epilepsy diagnosis is based upon clinical criteria and typical\n electroencephalographic findings (generalized pattern of spikes and\/or\n polyspikes and waves). All other tests are normal. Treatment and Prognosis.\n Both medical treatment and counselling are important in the management of\n juvenile myoclonic epilepsy. Mono-therapy with valproate is the preferred\n treatment. Some of the newer antiepileptic drugs have been suggested as\n possible alternatives. Juvenile myoclonic epilepsy has a good prognosis.\n Lifelong treatment is usually considered necessary in vast majority of\n patients due to the increased risk of relapse if treatment is discontinued.\n Conclusion. Juvenile myoclonic epilepsy is a common, although under-diagnosed\n epileptic syndrome. The clinician should study the occurrence of myoclonic\n jerks and should consider atypical presentations.<\/jats:p>","DOI":"10.2298\/mpns1108381b","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T06:45:56Z","timestamp":1316673956000},"page":"381-385","source":"Crossref","is-referenced-by-count":1,"title":["Juvenile myoclonic epilepsy: Under-diagnosed syndrome"],"prefix":"10.2298","volume":"64","author":[{"given":"Ksenija","family":"Bozic","sequence":"first","affiliation":[{"name":"Klini\u010dki centar Vojvodine, Klinika za neurologiju, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ksenija","family":"Gebauer-Bukurov","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Vojvodine, Klinika za neurologiju, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petar","family":"Slankamenac","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Vojvodine, Klinika za neurologiju, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Knezevic-Pogancev","sequence":"additional","affiliation":[{"name":"Institut za zdravstvenu za\u0161titu dece i omladine Vojvodine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Sekulic","sequence":"additional","affiliation":[{"name":"Kklini\u010dki centar Vojvodine, Klinika za neurologiju, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.9.1487"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05316.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000162856.75391.b1"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1991.tb04708.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.6.497"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00386.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.11.2101"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01948.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1535-7511.2007.00171.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1086\/377006"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.79.928.78"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1997.tb00207.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250411"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.4.1039"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb02432.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl048"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnp.0000228496.66246.e0"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2005000300003"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.2001.0662"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb02433.x"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1992.tb01706.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200103050-00006"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2005000500001"}],"container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:22:57Z","timestamp":1685352177000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81051108381B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":23,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns1108381b","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"value":"0025-8105","type":"print"},{"value":"1820-7383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}