{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:07:47Z","timestamp":1685419667246},"reference-count":0,"publisher":"National Library of Serbia","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Introduction. Chronic hepatitis C currently represents a global health\n   problem, which is expected to be reduced by pegylated-interferon and\n   ribavirin therapy. Material and Methods. We examined 88 patients with chronic\n   hepatitis C, divided into three groups according to their comorbidity: the\n   patients without comorbidity were in group I, group II included the patients\n   on dialysis, and group III included the patients with hemophilia. Results. A\n   significant difference was found in the percentage of achieved sustained\n   virological response between the patients on dialysis and other patients,\n   p&lt;0.05. Having analyzed the therapy adverse effects, we observed a\n   significantly higher decrease of erythrocytes count, hemoglobin and\n   hematocrit levels in dialysis patients compared to others (p&lt;0.01). The\n   patients on hemodialysis predominantly had anemia and leukopenia, while\n   thrombocytopenia was equally present in all groups. The dominant clinical\n   side effect was flu-like syndrome, present in more than a half of patients.\n   Discussion. The therapy positive effect is usually accompanied with adverse\n   effects. The lowest therapeutic response was recorded in group II, due to the\n   virus genotype 1. A significant decrease in hematological parameters was\n   determined in all patients. The most common clinical adverse effect was\n   flu-like syndrome, later manifestations included: weight loss, alopecia,\n   insomnia and irritability. Side effects like psychosis, thyroid gland\n   dysfunction or psoriasis were not recorded. Conclusion. A significant\n   decrease in the value of all these hematological parameters was found in all\n   groups of patients. Clinical side effects were present in 60% of patients.\n   Side effects did not lead to discontinuation of therapy, but only to\n   modification of drug doses.<\/jats:p>","DOI":"10.2298\/mpns1204106k","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T11:00:36Z","timestamp":1334746836000},"page":"106-110","source":"Crossref","is-referenced-by-count":1,"title":["Side effects of antiviral therapy in patients with chronic hepatitis C infection"],"prefix":"10.2298","volume":"65","author":[{"given":"Velimir","family":"Kostic","sequence":"first","affiliation":[{"name":"Klini\u010dki centar Ni\u0161, Klinika za infektivne bolesti, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Ni\u0161, Klinika za infektivne bolesti, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Radovic","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stevan","family":"Vujic","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:23:13Z","timestamp":1685352193000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81051204106K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns1204106k","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"value":"0025-8105","type":"print"},{"value":"1820-7383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}