{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T20:56:07Z","timestamp":1712350567219},"reference-count":0,"publisher":"National Library of Serbia","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Introduction. Duodenogastric reflux, commonly encountered as an aftermath of\n   gastroenteroanastomosis, with or without gastric resection (Billroth I,\n   Billroth II), vagotomy and pyloroplastic surgery, is known to cause\n   inflammatory-dystrophic-metaplastic lesions of gastric mucosa. Our objective\n   was to determine the effects of surgery-induced duodenogastric reflux on the\n   development of precarcinogenic lesions or carcinoma in correlation with the\n   reflux duration. Material and Methods. The experiment was performed on three\n   groups of Wistar rats with 1) Billroth II-induced reflux surgery, 2)\n   resection of the Roux-en-Y type reconstruction, and 3) control group with no\n   resection. The aim of the experiment was to study the effects of\n   duodenogastric reflux on the rat gastric mucosa in correlation with two\n   different types of gastroenteroanastomosis 8, 16 and 24 weeks after the\n   surgery. Results. In Billroth II group, hyperplastic changes were observed as\n   early as in week 16. Statistically significant results were recorded in week\n   24, with 6.7% of metaplastic alterations, including dysplasia of all three\n   degrees, dominantly severe dysplasia in 66.67%, early carcinoma in 20% and\n   gastric carcinoma in 6.67%. In the Roux-en-Y group, gastric mucosa remained\n   predominantly normal (60%), with somewhat increased frequency of gastritis\n   and dysplasia in week 24. In the control group, the finding of normal gastric\n   mucosa was constant. Conclusion. The experiment confirms that direct contact\n   of duodenal juice with gastric mucosa associated with Billroth II resection\n   causes precarcinogenic lesions. Development of adenocarcinoma caused solely\n   by duodenogastric reflux, excluding a carcinogenic agent is possible 20 weeks\n   after the experiment - earlier than suggested by previous researchers.<\/jats:p>","DOI":"10.2298\/mpns1308285z","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T10:50:07Z","timestamp":1375095007000},"page":"285-291","source":"Crossref","is-referenced-by-count":5,"title":["The role of duodenogastric reflux in formation of precarcinogenic gastric lesions: An experimental study"],"prefix":"10.2298","volume":"66","author":[{"given":"Aleksandar","family":"Zlatic","sequence":"first","affiliation":[{"name":"Clinical Centre Ni\u0161, General Surgery Clinic, Ni\u0161 + Medical faculty, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"Clinical Centre Ni\u0161, General Surgery Clinic, Ni\u0161 + Medical faculty, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Mihailovic","sequence":"additional","affiliation":[{"name":"Medical faculty, Ni\u0161 + Clinical Centre Ni\u0161, Institute for Pathology, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biljana","family":"Radovanovic-Dinic","sequence":"additional","affiliation":[{"name":"Medical faculty, Ni\u0161 + Clinical Centre Ni\u0161, Gastroenterology and Hepathology Clinic, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mladjan","family":"Protic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Vojvodina, Department for Abdominal, Endocrinal and Transplantation Surgery, Novi Sad + Medical Faculty, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radovan","family":"Veljkovic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Vojvodina, Department for Abdominal, Endocrinal and Transplantation Surgery, Novi Sad + Medical Faculty, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:24:11Z","timestamp":1685352251000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81051308285Z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns1308285z","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"value":"0025-8105","type":"print"},{"value":"1820-7383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}