{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:58:05Z","timestamp":1747209485473,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Introduction. Early detection of recurrence is an important factor for long\n   term survival of patients with colorectal cancer. Measurement of serum levels\n   of carcinoembryonic antigen has been commonly used in the postoperative\n   surveillance of colorectal cancer. The purpose of this study was to evaluate\n   the ability of positron emission tomography-computed tomography to detect\n   pathological substrate of elevated serum carcinoembryonic antigen in patients\n   with colorectal cancer. Material and Methods. The patients with colorectal\n   cancer who underwent curative surgical resection and\/ or chemotherapy, who\n   were found in our database, were analyzed retrospectively. Forty-eight 18F-\n   fluorodeoxyglucose positron emission tomography-computed tomography studies\n   including 45 patients (14 women, 31 men; mean age: 62.93 years) with elevated\n   serum, carcinoembryonic antigen levels, which had been performed between\n   January 2011 and January 2014, were evaluated. Serum levels of\n   carcinoembryonic antigen were measured within 3 months after positron\n   emission tomography-computed tomography examination. Final diagnosis of\n   recurrence was made by histopathological findings, radiology studies or\n   clinical follow-up. Results. Recurrences were diagnosed in 37 patients, the\n   prevalence being 77.1%. Liver metastases were found in 18 patients,\n   abdominal, pelvic and\/or mediastinal lymph nodes were positive in 19\n   patients, 11 patients had loco regional recurrences and 4 patients had\n   pulmonary metastasis, and bone metastases were found in one patient. One\n   patient was diagnosed with metastasis in scar tissue. The overall sensitivity\n   and specificity of positron emission tomography-computed tomography was\n   90.24% and 71.42%, respectively. The positive and negative predictive values\n   were 94.87% and 55.56%, respectively. Conclusion. 18F- fluorodeoxyglucose\n   positron emission tomography-computed tomography is a powerful tool that\n   could be used in determining colorectal cancer recurrence in patients with\n   elevated carcinoembryonic antigen levels and could have an important clinical\n   impact on the management in patients with suspected recurrent colorectal\n   cancer.<\/jats:p>","DOI":"10.2298\/mpns1512376m","type":"journal-article","created":{"date-parts":[[2015,12,25]],"date-time":"2015-12-25T15:47:22Z","timestamp":1451058442000},"page":"376-381","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic role of fluorine-18 (18F) fluorodeoxyglucose positron emission tomography computed tomography in detecting recurrent disease in patients with colorectal cancer and elevated carcinoembryonic antigen"],"prefix":"10.2298","volume":"68","author":[{"given":"Emil","family":"Matovina","sequence":"first","affiliation":[{"name":"Oncology Institute of Vojvodina, Department of Nuclear Medicine, Sremska Kamenica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6400-4495","authenticated-orcid":false,"given":"Jasna","family":"Mihailovic","sequence":"additional","affiliation":[{"name":"Oncology Institute of Vojvodina, Department of Nuclear Medicine, Sremska Kamenica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Nikoletic","sequence":"additional","affiliation":[{"name":"Oncology Institute of Vojvodina, Department of Nuclear Medicine, Sremska Kamenica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Srbovan","sequence":"additional","affiliation":[{"name":"Oncology Institute of Vojvodina, Department of Nuclear Medicine, Sremska Kamenica"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:25:12Z","timestamp":1685352312000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81051512376M"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns1512376m","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"type":"print","value":"0025-8105"},{"type":"electronic","value":"1820-7383"}],"subject":[],"published":{"date-parts":[[2015]]}}}