{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:58:05Z","timestamp":1747209485682,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Introduction. Streptococcus pneumoniae is one of the most common causes of\n   respiratory infections. The aim was to study the susceptibility to\n   antimicrobial agents of respiratory isolates of Streptococcus pneumoniae\n   obtained from hospitalized children. Material and Methods. A total of 190\n   respiratory pneumococcal isolates obtained from children aged from 0 to 14\n   years were isolated and identified by using standard microbiological methods.\n   Susceptibility to oxacillin, erythromycin, clindamycin, tetracycline,\n   cotrimoxazole, ofloxacin and rifampicin was tested by disc diffusion method.\n   Minimal inhibitory concentrations for amoxicillin and ceftriaxone were\n   determined by means of E test. The macrolide-resistant phenotype was detected\n   by double disc diffusion test. Results. All tested isolates were susceptible\n   to amoxicillin and ceftriaxone. The minimal amoxicillin concentration\n   inhibiting the growth of 50% of isolates and of 90% of isolates was 0.50\n   ?g\/ml and 1.0 ?g\/ml, respectively and the minimal ceftriaxone concentration\n   inhibiting the growth of 50% of isolates and of 90% of isolates was 0.25\n   ?g\/ml and 0.50 ?g\/ml, respectively. Susceptibility to erythromycin and\n   clindamycin was observed in 21.6% and 29.47% of isolates, respectively. The\n   resistence to macrolides - M phenotype was detected in 10.07% of isolates and\n   constitutive macrolide-lincosamide-streptogramin phenotype (constitutive MLS\n   phenotype) was found in 89.93% of isolates. All tested isolates were\n   susceptible to ofloxacin and rifampicin. Conclusion. Amoxicillin could be the\n   therapy of choice in pediatric practice. The macrolides should not be\n   recommended for the empirical therapy of pneumococcal respiratory tract\n   infection in our local area.<\/jats:p>","DOI":"10.2298\/mpns1604110d","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T13:38:03Z","timestamp":1460727483000},"page":"110-114","source":"Crossref","is-referenced-by-count":2,"title":["Susceptibility of respiratory isolates of Streptococcus pneumoniae isolated from children hospitalized in the Clinical center Nis"],"prefix":"10.2298","volume":"69","author":[{"suffix":"M.","given":"Marina","family":"Dinic","sequence":"first","affiliation":[{"name":"Institute for Public Health, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snezana","family":"Mladenovic-Antic","sequence":"additional","affiliation":[{"name":"Institute for Public Health, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branislava","family":"Kocic","sequence":"additional","affiliation":[{"name":"Institute for Public Health, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8648-8769","authenticated-orcid":false,"given":"Dobrila","family":"Stankovic-Djordjevic","sequence":"additional","affiliation":[{"name":"Institute for Public Health, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8442-7460","authenticated-orcid":false,"given":"Miodrag","family":"Vrbic","sequence":"additional","affiliation":[{"name":"Clinical Center, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"Institute for Public Health, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:25:23Z","timestamp":1685352323000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81051604110D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns1604110d","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"type":"print","value":"0025-8105"},{"type":"electronic","value":"1820-7383"}],"subject":[],"published":{"date-parts":[[2016]]}}}