{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:44:07Z","timestamp":1774356247866,"version":"3.50.1"},"reference-count":0,"publisher":"National Library of Serbia","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Introduction. It has been generally accepted that the benefits of menopausal\n   hormone therapy outweigh the risks, but there are still some concerns about\n   the administration of menopausal hormone therapy, which has introduced\n   alternative treatments. Pharmacological Alternatives. Central alpha-2 agonist\n   clonidine is only marginally more effective than placebo, and significantly\n   less effective than estrogen. Antiepileptic drug gabapentin reduces hot\n   flashes; however, it is less effective than estrogen. Selective serotonin\n   reuptake inhibitors (paroxetine and fluoxetine) and selective noradrenaline\n   reuptake inhibitors (venlafaxine) reduce vasomotor symptoms and improve\n   depression, anxiety and sleep. Results of studies about\n   dehydroepiandrosterone effects on menopausal symptoms are inconsistent and\n   additional investigations are needed. Non-Pharmacological Alternatives.\n   Stellatum ganglion blockade is a successful treatment for reducing vasomotor\n   symptoms in patients with contraindications for menopausal hormone therapy.\n   Efficacy of acupuncture, homeopathy and reflexology should be proved by\n   adequate studies. Phytoestrogens could reduce vasomotor symptoms but to a\n   lesser extent than conventional menopausal hormone therapy. However, they\n   have not been proved yet to provide cardiovascular protection and prevention\n   of osteoporosis, nor they could be recommended instead of traditional\n   menopausal hormone therapy. There is a concern about their undesirable\n   effects. Adequate diet, unchanging body weight within ideal values and\n   adequate physical activities have beneficial long-term effects, first of all\n   on preservation of bone density. Alternatives for Atrophic Changes of Vaginal\n   Epithelium. Menopausal symptoms resulting from vaginal atrophy could be\n   resolved by use of hydrophilic preparations, lubricants and topical lidocaine\n   cream or 4% lidocaine water solution for dyspareunia. Conclusion. If there\n   are contrain?dications to menopausal hormone therapy or patients are\n   unwilling to take hormone therapy, alternative treatments, which can also\n   solve menopausal symptoms, should be considered.<\/jats:p>","DOI":"10.2298\/mpns1606177k","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T16:53:45Z","timestamp":1465577625000},"page":"177-182","source":"Crossref","is-referenced-by-count":3,"title":["Alternatives of menopausal hormone therapy"],"prefix":"10.2298","volume":"69","author":[{"suffix":"M.","given":"Ranko","family":"Kutlesic","sequence":"first","affiliation":[{"name":"Clinical Centre Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161 + Faculty of Medicine, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmina","family":"Popovic","sequence":"additional","affiliation":[{"name":"Clinical Centre Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161 + Faculty of Medicine, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Clinical Centre Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161 + Faculty of Medicine, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Predrag","family":"Vukomanovic","sequence":"additional","affiliation":[{"name":"Clinical Centre Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161 + Faculty of Medicine, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojan","family":"Lukic","sequence":"additional","affiliation":[{"name":"Clinical Centre Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Lilic","sequence":"additional","affiliation":[{"name":"Clinical Centre Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:25:29Z","timestamp":1685352329000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81051606177K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns1606177k","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"value":"0025-8105","type":"print"},{"value":"1820-7383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}