{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:58:06Z","timestamp":1747209486829,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Case report. A 41-year-old man presented with anemia, lymphocytosis and\n   splenomegaly. T-cell large granular lymphocyte leukemia was diagnosed based\n   on lymphocytosis of T-cell large granular lymphocytes, characteristic\n   immunophenotype (CD3+, CD8+, CD16+, CD57+) of the lymphocytes and clonally\n   rearranged T-cell receptor genes. Therapy indication was\n   transfusion-dependent anemia. Initial cyclosporine therapy and low-dose\n   oral methotrexate failed to control anemia and lymphocytosis. Yet, a\n   complete clinical and hematological response (without molecular remission)\n   was achieved and sustained when cyclosporine was reintroduced into the\n   therapy. Conclusion. Our case confirms that cyclosporine therapy is\n   effective in treating T-cell large granular lymphocyte leukemia and suggests\n   that indefinite treatment may not be needed to maintain the response.<\/jats:p>","DOI":"10.2298\/mpns1612376z","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T13:19:44Z","timestamp":1485177584000},"page":"376-378","source":"Crossref","is-referenced-by-count":1,"title":["The case of T-cell large granular lyphocyte leukemia presented as transfusion dependent anemia with sustained response to cyclosporine a therapy: Case report"],"prefix":"10.2298","volume":"69","author":[{"given":"Vanja","family":"Zeremski","sequence":"first","affiliation":[{"name":"University Hospital Magdeburg, Department of Hematology and Oncology, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5619-3724","authenticated-orcid":false,"given":"Aleksandar","family":"Savic","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Department of Hematology, Novi Sad + Faculty of Medicine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Cemerikic-Martinovic","sequence":"additional","affiliation":[{"name":"Pathohistology Laboratory Beolab, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5014-8949","authenticated-orcid":false,"given":"Ivana","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Department of Hematology, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7006-9199","authenticated-orcid":false,"given":"Marina","family":"Dragicevic","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Department of Hematology, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Amir","given":"Farra","family":"El","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Department of Hematology, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:25:39Z","timestamp":1685352339000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81051612376Z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns1612376z","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"type":"print","value":"0025-8105"},{"type":"electronic","value":"1820-7383"}],"subject":[],"published":{"date-parts":[[2016]]}}}