{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:25:54Z","timestamp":1757780754917,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med pregl","MED PREGLED"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Introduction. The major oxygen sensors in the human body are peripheral\n   chemoreceptors, also known as interoreceptors-as connected with internal\n   organs, located in the aortic arch and in the body of the common carotid\n   artery. Chemoreceptor function under physiological conditions. Stimulation\n   of peripheral chemoreceptors during enviromental hypoxia causes a\n   reflex-mediated increased ventilation, followed by the increase of the\n   muscle sympatic activity, aiming to maintain tissue oxygen homeostatis, as\n   well as glucosae homeostatis. Besides that, peripheral chemoreceptors\n   interact with central chemoreceptors, responsible for carbon dioxide\n   changes, and they are able to modulate each other. Chemoreceptor function\n   in pathophysiological conditions. Investigations of respiratory function in\n   many pathological processes, such as hypertension, obstructive sleep apnea,\n   congestive heart failure and many other diseases that are presented with\n   enhanced peripheral chemosensitivity and impaired functional sympatholysis\n   ultimately determine the peripheral chemoreceptor role and significance of\n   peripheral chemoreceptors in the process of those pathological conditions\n   development. Considering this, the presumed influence of peripheral\n   chemoreceptors is important in patients having the above mentioned\n   pathology. Conclusion. The importance and the role of peripheral\n   chemoreceptors in the course of the breathing control is still\n   controversial, despite many scientific attempts to solve this problem. The\n   main objective of this review is to give the latest data on the peripheral\n   chemoreceptor role and to highlight the importance of peripheral\n   chemoreceptors for maintaining of oxygen homeostasis in pateints with\n   hypoxia caused by either physiological or pathological conditions.<\/jats:p>","DOI":"10.2298\/mpns1612385l","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T13:19:44Z","timestamp":1485177584000},"page":"385-390","source":"Crossref","is-referenced-by-count":5,"title":["The regulation role of carotid body peripheral chemoreceptors in physiological and pathophysiological conditions"],"prefix":"10.2298","volume":"69","author":[{"given":"Biljana","family":"Lazovic","sequence":"first","affiliation":[{"name":"University Clinical Hospital Center \u201cZemun\u201d, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7123-140X","authenticated-orcid":false,"given":"Mirjana","family":"Zlatkovic-Svenda","sequence":"additional","affiliation":[{"name":"School of Medicine, Pulmonology Unit, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tijana","family":"Durmic","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Rheumatology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Stajic","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Medical Physiology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Djuric","sequence":"additional","affiliation":[{"name":"Institute for Health Protection of the Ministry of Interior, Department of Cardiology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Zugic","sequence":"additional","affiliation":[{"name":"University Clinical Hospital Center \u201cBe\u017eamijska Kosa\u201d, Belgrade + Clinical Center of Serbia, Clinic for Lung Diseases, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Medicinski pregled","Medical review"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:25:40Z","timestamp":1685352340000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0025-81051612385L"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2298\/mpns1612385l","relation":{},"ISSN":["0025-8105","1820-7383"],"issn-type":[{"type":"print","value":"0025-8105"},{"type":"electronic","value":"1820-7383"}],"subject":[],"published":{"date-parts":[[2016]]}}}