{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:57:54Z","timestamp":1747209474349,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"suppl. 1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>INTRODUCTION. Recurrent coarctation is a complication which is seen at a\n   consistent rate following repair for coarctation of the aorta in young\n   infants. OBJECTIVE. This retrospective analysis was carried out to compare\n   the results between resection with end-to-end anastomosis (ETE), and\n   resection with extended end-to-end anastomosis (E-ETE), in this age group\n   during late follow-up period. The role of ductus arteriosus is not clearly\n   defined and the second objective of this study was to analyze intimal\n   thickening in aortic coarctation. MATERIAL AND METHODS. From 1999 to 2003, 45\n   patients less than 3 months of age un?derwent repair of aortic coarctation.\n   Mean age was 24 days (2-89 days), average weight was 3.5?0.6 kg (2.4-5.2 kg).\n   The method of repair was ETE in 14 (31.1%) patients, E-ETE in 29 (64.4%)\n   patients and other techniques were applied in 2 cases. Demographic,\n   morphometric, clinical and operative variables were analyzed for correlation\n   with recurrent arch obstruction. In order to characterize the components of\n   intimal thickening in coarctation, narrowed segments of aorta resected from\n   16 neonates during surgery were examined immunocytochemically and by electron\n   microscopy. For light microscopy, the specimens were dehydrated in graded\n   ethanol (70-100%), cleared in xylol and embedded in paraffin.\n   Immunocytochemical staining was performed in 5 ?m sections from\n   formaldehyde-fixed paraffin-embedded blocks, using a labeled\n   streptavidin-biotin method with an LSkit (Dako). RESULTS. Early mortality\n   was 6.7% (CI 95%, 2.9%-10.4%). All early deaths (3 patients) occurred in\n   infants with associated ventricular septal defects (p&lt;0.05). The mean\n   follow-up for all patients was 30?21 months (range 1.5-63 months). During\n   mean follow-up of 2 months, recurrent arch obstruction was diagnosed in 9\n   patients (21.4%). Two patients with associated complex heart defects died\n   before reintervention, one had mild gradient on catheterization (20 mm Hg)\n   and one is waiting for catheterization. Five patients were reoperated and the\n   mean time to reintervention was 4 months (range 2.6-6 months). Kaplan-Meier\n   freedom from recoarctation was 78.1?6.4% at 5 years in the whole group.\n   Freedom from recoarctation was 60.6?15.4% at 25 months in ETE group and\n   86.2?6.4% at 60 months in E-ETE group (p=0.062). Factors associated with\n   recoarctation, obtained by univariable Cox regression, included abnormal\n   right subclavian artery (p=0.003), hypoplastic proximal transverse aortic\n   arch (Z?-2, p=0.025) and weight at op?eration ?3 kg (p=0.02). Abnormal origin\n   of the right subclavian artery was the only independent predictor of\n   recoarctation obtained by multivariable Cox regression analysis. DISCUSSION.\n   All examined specimens had intimal thickening of the posterior aortic wall,\n   with accumulation of smooth muscle cells (SMC) with ? smooth muscle actin\n   (?-SMA) and vimentin-immunoreactivity (but not desmin and MHC) and also\n   expressed PCNA and S-100. In the inner media of the anteromedial wall of the\n   aorta, all specimens had large number of SMC expressing desmin and MHC. SMC\n   in the inner media exhibit contractile phenotype and their origin could be\n   ductal. CONCLUSION. Both procedures are effective for coarctation repair in\n   young infants. Risk of recoarctation is a function of the complex anatomy of\n   the arch, while residual ductal tissue may play a significant role.<\/jats:p>","DOI":"10.2298\/sarh04s1027i","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T14:43:00Z","timestamp":1432132980000},"page":"27-33","source":"Crossref","is-referenced-by-count":1,"title":["For coarctation of the aorta in infants younger than three months"],"prefix":"10.2298","volume":"132","author":[{"given":"Slobodan","family":"Ilic","sequence":"first","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Vukovic","sequence":"additional","affiliation":[{"name":"University School of Medicine, Institute of Histology and Embryology, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djordje","family":"Hercog","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Vucicevic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Voja","family":"Parezanovic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Vukomanovic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7726-4982","authenticated-orcid":false,"given":"Milan","family":"Djukic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slavko","family":"Simeunovic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Lackovic","sequence":"additional","affiliation":[{"name":"University School of Medicine, Institute of Histology and Embryology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Todorovic","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:21:41Z","timestamp":1685355701000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817904027I"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":0,"journal-issue":{"issue":"suppl. 1","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh04s1027i","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"type":"print","value":"0370-8179"},{"type":"electronic","value":"2406-0895"}],"subject":[],"published":{"date-parts":[[2004]]}}}