{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:57:54Z","timestamp":1747209474253,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"suppl. 1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>It is certain that in the past the types of bacterial agents responsible for\n   neonatal sepsis and their sensitivity to antibiotics were not the same in all\n   historical periods. However, the reports confirming the conclusion have been\n   published only in the last three years. According to these facts, the\n   bacterial causes of neonatal sepsis were analyzed in patients treated at the\n   University children?s hospital in Belgrade (S&amp;M) as well as their sensitivity\n   to antibiotics to determine the most effective initial therapy. Between\n   January 2001 and June 2004, 35 neonates, aged from 1-30 days, with positive\n   blood culture were treated. Gram-negative bacteria were the cause of sepsis\n   in 57% of patients (Pseudomonas - 20%, Klebsiella - 20%, E. coli - 8,5%,\n   Acinetobacter - 8.5%), gram-positive in 43% (coagulase-negative Staphylococci\n   - 14%, Staphylococcus epidermidis - 14%, Staphylococcus aureus - 9%,\n   Streptococcus group B - 3%, Listeria monocytogenes - 3%). The bacteria were\n   the most sensitive to carbapenems (85-89%), amikacin (68%), third-generation\n   cephalosporins (47-50%), while the sensitivity to gentamicin was less than\n   expected (48.5%). Sensitivity to ampicillin (8%) confirmed a high level of\n   resistance to this antibiotic. All isolated Staphylococci were sensitive to\n   vancomycin, and the overall methicillin resistance was 46%. Combined\n   cefotaxime and amikacin therapy was the most effective of all suggested\n   initial combinations of antibiotics (74%). The sensitivity to all other\n   combinations of antibiotics was 51-71%. The most adequate initial combination\n   of antibiotics for the treatment of neonatal sepsis is cefotaxime plus\n   amikacin. The most adequate antibiotic for the treatment of nosocomial\n   neonatal sepsis is carbapenem.<\/jats:p>","DOI":"10.2298\/sarh04s1049j","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T14:43:00Z","timestamp":1432132980000},"page":"49-53","source":"Crossref","is-referenced-by-count":0,"title":["Initial antibiotic therapy of neonatal sepsis"],"prefix":"10.2298","volume":"132","author":[{"given":"Milos","family":"Jesic","sequence":"first","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Jesic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svjetlana","family":"Maglajlic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Lukac","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Sindjic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7738-7018","authenticated-orcid":false,"given":"Dragana","family":"Vujovic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodanka","family":"Grkovic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:22:00Z","timestamp":1685355720000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817904049J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":0,"journal-issue":{"issue":"suppl. 1","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh04s1049j","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"type":"print","value":"0370-8179"},{"type":"electronic","value":"2406-0895"}],"subject":[],"published":{"date-parts":[[2004]]}}}