{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:28:16Z","timestamp":1788366496508,"version":"build-2803163510"},"reference-count":0,"publisher":"National Library of Serbia","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Autoimmune diseases are manifested in a broad spectrum. Classic examples of\n   organ-specific autoimmune disease include Addison?s disease,\n   insulin-dependent type-1 Diabetes mellitus, Grave?s disease (MGB), and\n   Hashimoto thyroiditis (HT). The initial report of this autoimmune thyroid\n   disease (AITD) dates back to Hakira Hashimoto (1912). In HT, as an\n   organ-specific autoimmune disease, massive infiltration of lymphoid cells and\n   parenchyma destruction are a consistent feature. The infiltration appears to\n   be immune-mediated, primarily lymphocytic (T helper, T suppressor cells), NK\n   cells and B cells. The pathological characteristics of AITD include\n   development of the goitre (atrophic form is not so frequent), impaired\n   thyroid gland function (from hyperthyroidism to subclinical and manifested\n   hypothyroidism) and the formation of antithyroidal antibodies against\n   thyroglobulin (AbTg) and the microsomal antigen (Ab TPO). There is a very\n   good correlation between the antibodies against TPO and the histological\n   findings. Morbus Graves Basedow is characterized by autoimmune\n   hyperthyroidism with goitre, and infiltrative orbitopathy. Autoantibodies\n   against the TSH-receptor molecule on the plasma membrane of the thyroid gland\n   follicles cause a nonphysiological activation and an increase of the cellular\n   function. Besides this hyperthyroidal condition, an autoimmune attack against\n   the retrobulbar tissue leading to endocrine orbitopathy, can be noted in\n   about 40% of patients suffering from MGB.<\/jats:p>","DOI":"10.2298\/sarh05s1016d","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T13:38:44Z","timestamp":1438263524000},"page":"16-24","source":"Crossref","is-referenced-by-count":3,"title":["Autoimmune thyroid disease and associated autoimmunity"],"prefix":"10.2298","volume":"133","author":[{"given":"Snezana","family":"Djurica","sequence":"first","affiliation":[{"name":"Clinical Hospital Centre \u201eZvezdara\u201d, Department of Internal Medicine, Centre for Thyroid Gland Diseases and Hormone Induced Osteoporosis, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozo","family":"Trbojevic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute Endocrinology, Diabetes and Metabolic Disorders, Belgrade;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"P.","given":"Dragoslav","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Clinical Hospital Centre \u201eZvezdara\u201d, Clinic for Geriatrics, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"Markovic","sequence":"additional","affiliation":[{"name":"Clinical Hospital Centre \u201eZvezdara\u201d, Department of Internal Medicine, Centre for Cardiovascular Diseases, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:23:02Z","timestamp":1685355782000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817905016D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":0,"journal-issue":{"issue":"Suppl. 1","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh05s1016d","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}