{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:27:50Z","timestamp":1792124870125,"version":"4.4.0"},"reference-count":0,"publisher":"National Library of Serbia","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Changes of the affective and cognitive function are usually associated with\n   thyroid gland dysfunction. In autoimmune thyroid disease, these changes can\n   be caused by thyroid dysfunction (hypo- or hyperthyroidism) or associated\n   with the presence of antithyroid antibodies. Even a small change in thyroid\n   hormone concentration is associated with change of cognitive function. In\n   euthyroid older males, variation of total and free thyroxin accounts for\n   about 10% of Wechsler adult intelligence test variance. In euthyroid females,\n   lower cognitive function, measured by Mini Mental test, also correlates with\n   blood thyroxin. Short-term (4 weeks) hypothyroidism induces clinically\n   significant cognitive dysfunction, which is reversible by thyroid hormone\n   substitution. Mild hypothyroidism (TSH less than 10) also induces reversible\n   cognitive dysfunction. In hypothyroidism, PET scanning shows global reduction\n   of brain blood flow and glucose metabolism. Hashimoto?s encephalopathy is\n   characterized by corticosteroid reversible encephalopathy associated with the\n   presence of antithyroid antibodies. Encephalopathy can be manifested as\n   multiple stroke-like episodes (vasculitis like), or as diffuse, progressive\n   type characterized by dementia and psychiatric symptoms. In euthyroid\n   patients with Hashimoto?s thyroiditis and no evidence of neurological\n   disease, SPECT showed brain perfusion abnormalities. Post mortem and brain\n   biopsy findings can be normal or show perivascular lymphocytic infiltration.\n   Recently, presence of antineuronal antibodies has been found in patients with\n   Hashimoto?s thyroiditis. Specific high reactivity against human ?-enolase was\n   high in patients with Hashimoto?s encephalopathy, but absent in patients with\n   other neurological disorders and healthy subjects. Specific antineural\n   antibodies were found in another group of Hashimoto?s encephalopathy\n   patients. Furthermore, Ferracci et al, found antithyroid antibodies in the\n   CSF of patients with Hashimoto?s encephalopathy.<\/jats:p>","DOI":"10.2298\/sarh05s1088z","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T13:38:44Z","timestamp":1438263524000},"page":"88-91","source":"Crossref","is-referenced-by-count":5,"title":["Autoimmune thyroid disease and brain"],"prefix":"10.2298","volume":"133","author":[{"given":"Milos","family":"Zarkovic","sequence":"first","affiliation":[{"name":"Clinical Centre of Serbia, Institute of Endocrinology, Diabetes and Metabolic Disorders, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:23:45Z","timestamp":1685355825000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817905088Z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":0,"journal-issue":{"issue":"Suppl. 1","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh05s1088z","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}