{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:10:49Z","timestamp":1685419849167},"reference-count":0,"publisher":"National Library of Serbia","issue":"Suppl. 3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>INTRODUCTION. HELLP syndrome represents the form of preeclampsia\n   characterized by moderate hypertension, often with absence of proteinuria and\n   oedema. The frequency of HELLP syndrome in pregnant women with preeclampsia\n   is 10-20%. The clinical course of the disease is characterized by the\n   progressive worsening of mother and fetus condition, which can be stopped\n   only by delivery. Disseminated intravascular coagulation is present in 8% of\n   patients with HELLP syndrome and causes significant morbidity and mortality.\n   CASE OUTLINE. We present a case of HELLP syndrome complicated by intrauterine\n   fetal demise and disseminated intravascular coagulation in trigemelar\n   pregnancy. After all surgical and medicamentous methods to establish\n   haemostasis were exhausted, the patient was treated by recombinant activated\n   factor VII (rFVIIa) in intravenous bolus dose of 90 ?g\/kg twice, which\n   resulted in satisfactory haemostasis. Side effects of the drug were not\n   registered. CONCLUSION. The application of rFVIIa reduced haemorrhage in our\n   patient, both after the Caesarean section and after hysterectomy,\n   contributing to the patient?s full recovery, without neurological sequelae\n   and with preserved renal function. RFVIIa is not an alternative to surgical\n   haemostasis, but its administration should surely be considered before\n   deciding to perform hysterectomy, especially in patients who want to preserve\n   fertility. In cases of postpartum haemorrhage, when bleeding persists even\n   after adequate surgical haemostasis, the administration of rFVIIa is to be\n   considered not only as an alternative to hysterectomy, but also an effort to\n   prevent significant maternal morbidity and mortality.<\/jats:p>","DOI":"10.2298\/sarh08s3253i","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T11:24:37Z","timestamp":1438860277000},"page":"253-258","source":"Crossref","is-referenced-by-count":0,"title":["Successful application of recombinant activated factor VII in a patient with HELLP syndrome and disseminated intravascular coagulation"],"prefix":"10.2298","volume":"136","author":[{"given":"Tatjana","family":"Ilic-Mostic","sequence":"first","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Anesthesia and Reanimation, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajka","family":"Argirovic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Gynecology and Obstetrics, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radmila","family":"Sparic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Gynecology and Obstetrics, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Ljubic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Gynecology and Obstetrics, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Bozanovic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Gynecology and Obstetrics, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Jeremic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Gynecology and Obstetrics, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Tomanovic-Kokovic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Anesthesia and Reanimation, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasa","family":"Kadija","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Gynecology and Obstetrics, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:27:14Z","timestamp":1685356034000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817908253I"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":0,"journal-issue":{"issue":"Suppl. 3","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh08s3253i","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}