{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:08:31Z","timestamp":1685419711628},"reference-count":0,"publisher":"National Library of Serbia","issue":"Suppl. 4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>INTRODUCTION. Two types of hereditary nephritis, nonprogressive and\n   progressive, clinically present as asymptomatic haematuria, sometimes\n   combined with proteinuria. At the onset, in both types, light microscopic\n   changes are minimal, immunofluorescence findings are negative, and diagnosis\n   can be made only upon electron microscopic findings that are considered to be\n   specific. OBJECTIVE. The aim of this study was to determine the significance\n   of Goodpasture antigen detection in diagnosis of progressive and\n   nonprogressive hereditary nephritis in its early phase. METHOD. Analysis of\n   renal biopsy specimens was done in patients with hereditary nephritis that\n   were followed from 1990 to 2005. Progression of renal disease was examined in\n   14 patients with Alport?s syndrome, 10 patients with thin basement membrane\n   disease, and 6 patients with unclassified hereditary nephritis diagnosed. For\n   all these cases, indirect immunofluorescence study with serum from a patient\n   with high titer of Goodpasture autoantibodies that recognize the antigenic\n   determinants in human glomerular and tubular basement membrane was performed.\n   RESULTS. In 11 out of 14 cases diagnosed as Alport?s syndrome, there was\n   negative staining with Goodpasture serum, and in 3 additional cases with\n   Alport?s syndrome, expression of Goodpasture antigen in glomerular basement\n   membrane and thin basement membrane was highly reduced. In all 10 patients\n   with thin basement membrane disease, immunofluorescence showed intensive,\n   bright linear staining with Goodpasture serum along glomerular and tubular\n   basement membrane. In 2 out of 6 patients with unclassified hereditary\n   nephritis, Goodpasture antigen expression was very strong, in one patient it\n   was very reduced, and in 3 patients it was negative. CONCLUSION. The results\n   of our study show that Goodpasture antigen detection plays a very important\n   role in differential diagnosis of progressive and nonpregressive hereditary\n   nephritis, particularly in early phases of the disease.<\/jats:p>","DOI":"10.2298\/sarh08s4282b","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T11:13:58Z","timestamp":1438859638000},"page":"282-286","source":"Crossref","is-referenced-by-count":0,"title":["The significance of Goodpasture antigen in hereditary nephritis"],"prefix":"10.2298","volume":"136","author":[{"given":"Gordana","family":"Basta-Jovanovic","sequence":"first","affiliation":[{"name":"School of Medicine, Institute of Pathology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Radojevic-Skodric","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Pathology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Pathology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Pathology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radovan","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"Institute for Mother and Child Health Protection of Serbia \u201cDr Vukan \u010cupi\u0107\u201d, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Visnja","family":"Lezaic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Nephrology and Urology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidosava","family":"Nesic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Nephrology and Urology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Dikman","sequence":"additional","affiliation":[{"name":"Mount Sinai School of Medicine, Department of Pathology, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:27:15Z","timestamp":1685356035000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817908282B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":0,"journal-issue":{"issue":"Suppl. 4","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh08s4282b","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}