{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:50:32Z","timestamp":1787025032352,"version":"build-2736575974"},"reference-count":0,"publisher":"National Library of Serbia","issue":"Suppl. 4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>INTRODUCTION. Polycystic kidney disease is an inherited kidney disease that\n   affects both kidneys and it is characterized by diffuse replacement of renal\n   parenchyma by thousands of microcysts. In time, renal insufficiency develops.\n   There are two forms of PKD: ADPKD, which is detected in adults (children are\n   rarely affected), and ARPKD, which is detected in neonates (later\n   presentations do occur, but rarely). OBJECTIVE. The aim of this study was to\n   analyse frequency of polycystic kidney disease, clinical data and\n   morphological characteristics. METHOD. At the Institute of Pathology, School\n   of Medicine, Belgrade, there were detected 33 cases of ADPKD and 20 cases of\n   ARPKD between 1987 and 2007. RESULTS. There were no differences between\n   incidence of ADPKD in males and females. Average age of patients with ADPKD\n   was 52 years. In 20 (66.7%) cases of ADPKD there were neither extrarenal\n   cysts nor extrarenal manifestations detected. In other 13 cases, we detected\n   extrarenal cysts: hepatic cysts in 8 cases, pancreatic cysts in 5 cases. In\n   two cases, hepatic cysts were associated with intracranial (arachnoid cysts)\n   and extracranial aneurysms. The most frequent cause of death in patients with\n   ADPKD was end-stage disease. ARPKD affects more often male children compared\n   to female. 70% of children with ARPKD were male. The mean age of patients\n   with ARPKD was 1 month. 5 patients (40%) had hepatic fibrosis. The most\n   frequent cause of death was respiratory insufficiency (75%). In 25% of\n   patients, the cause of death was sepsis and renal insufficiency. CONCLUSION.\n   Morphological and clinical manifestations of the analysed cases of both types\n   of PKD are fairly consistent with literature data. Better knowing of\n   aethiopathogenesis of PKD will facilitate early diagnosis, based on clinical\n   and morphological characteristics and better management of the disease.<\/jats:p>","DOI":"10.2298\/sarh08s4294r","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T07:13:58Z","timestamp":1438845238000},"page":"294-297","source":"Crossref","is-referenced-by-count":1,"title":["Polycystic kidney disease - autopsy review from the period 1987-2007"],"prefix":"10.2298","volume":"136","author":[{"given":"Sanja","family":"Radojevic-Skodric","sequence":"first","affiliation":[{"name":"School of Medicine, Institute of Pathology, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Pathology, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Pathology, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Baralic","sequence":"additional","affiliation":[{"name":"Velefarm AD Holding company, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Savin","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute for Nephrology and Urology, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Basta-Jovanovic","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Pathology, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T06:27:16Z","timestamp":1685341636000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817908294R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":0,"journal-issue":{"issue":"Suppl. 4","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh08s4294r","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}