{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T19:27:48Z","timestamp":1751916468610},"reference-count":0,"publisher":"National Library of Serbia","issue":"Suppl. 4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Autosomal dominant polycystic kiney disease is a hereditary systemic\n   disorder, characterized by the developement of cysts, mainly in the kidney\n   and liver, also with gastrointestinal and cardiovascular abnormalities. It\n   affects 4 to 6 million people wordwide and accounts for end-stage renal\n   disease in 7-10% of dialysis patients. The genetic penetrance is 100%, all\n   affected individuals develop renal cysts until 70 years of age, and because\n   of a great renal function reserve only about 50% of patients develop some\n   degree of renal failure until the age of 60. Autosomal dominant polycystic\n   kiney disease is a heterogeneous disorder, from a clinical as well as from a\n   genetic point of view. There are at least three genes responsible for the\n   disease: PKD-1 gene localized on chromosome 16p in the 16p13.3 segment which\n   encodes Polycystin 1 protein similar to membrane receptor, PKD-2 gene\n   localized on chromosome 4q in 4q13-23 segment which encodes Polycystin 2\n   protein wery similar to voltage L type Ca++ channel as well as Na+ channel\n   and PKD-3 gene of unknown localization. Specific proteins participate in\n   regulation od cell proliferation, apoptosis, secretion, polarity, cell-matrix\n   interactions as cell-cell interactions and lead to the developement of cystic\n   kidney disease. Renal manifestations of disease include structural (cyst\n   development), functional (concentration alility falls), endocrine (renin\n   erythropoietin) abnormalities and extra- renal manifestations. A routine\n   diagnostic methods are good case-history about cystic kidney disease in\n   family, ultrasonographic examination of kidneys and computerized tomography.\n   In therapy of autosomal dominant polycystic kiney disease, low protein diets\n   may help, treatment of arterial hypertension with ACE inhibitors and\n   angiotensin II receptor blockers, the vasopressin V2 antagonists (VSR),\n   rapamycin and long-acting somatostatin analogue may have some benefit.<\/jats:p>","DOI":"10.2298\/sarh08s4340p","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T11:13:58Z","timestamp":1438859638000},"page":"340-347","source":"Crossref","is-referenced-by-count":1,"title":["Autosomal dominant polycystic kidney disease"],"prefix":"10.2298","volume":"136","author":[{"given":"Steva","family":"Pljesa","sequence":"first","affiliation":[{"name":"Clinical Hospital Centre \u201cZemun\u201d, Nephrology Department, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:27:20Z","timestamp":1685356040000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817908340P"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":0,"journal-issue":{"issue":"Suppl. 4","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh08s4340p","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}