{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:13:38Z","timestamp":1780089218986,"version":"3.54.0"},"reference-count":13,"publisher":"National Library of Serbia","issue":"1-2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Introduction. Secondary lactose intolerance (SLI) belongs to the rarer manifestations of gluten-sensitive enteropathy (GSE). It occurs in more severe forms of the disease and its presence contributes significantly to the degree of its expression. Objective. The goal of the study was to determine the frequency of SLI in infants with clinically classic form of GSE, as well as its relationship with the duration, severity and age at the diagnosis of the basic disease and the degree of small bowel mucosa damage. Methods. The study was based on a sample of 42 infants, 30 female and 12 male, aged 7-12 months (x=9.98?1.69), with a clinically classic form of GSE. The diagnosis of GSE was established based on the characteristic pathohistological appearance of small bowel mucosa and clinical improvement of patients on gluten-free diet, while SLI on pathological lactose or milk tolerance test. The assessment of basic disease severity was based on body mass divergence in relation to the standard value, as well as on Hb and serum iron levels, while the degree of small bowel mucosa damage was determined according to the modified Marsh criteria. Results. SLI was verified in 8\/42 or 19.05% of patients. In addition to the symptoms and clinical signs of GSE, all the patients with SLI also featured the problems characteristic of lactose tolerance disorders, i.e. watery diarrhoea, borborygmus and meteorism occurring after milk meals. In addition, all had perianal erythema (6 with erosive changes), as well as destructive enteropathy (5 subtotal and 3 total). The difference in the duration of the basic disease, age at diagnosis, as well as in the degree of body mass deviation from the standard value between the lactose-tolerant and lactose-intolerant infants was not found. In addition, no difference in Hb and serum iron levels or in the degree of small bowel mucosa damage was found between the two groups. Conclusion. Our findings indicate that SLI presents a relatively frequent occurrence in infants with clinically classic GSE, as well as that it occurs independently to the duration, severity and age at diagnosis of the basic disease and the degree of small bowel mucosa damage.<\/jats:p>","DOI":"10.2298\/sarh0902033r","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T08:59:44Z","timestamp":1238057984000},"page":"33-37","source":"Crossref","is-referenced-by-count":12,"title":["Lactose intolerance in infants with gluten-sensitive enteropathy: Frequency and clinical characteristics"],"prefix":"10.2298","volume":"137","author":[{"given":"Nedeljko","family":"Radlovic","sequence":"first","affiliation":[{"name":"Univerzitetska de\u010dja klinika, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Mladenovic","sequence":"additional","affiliation":[{"name":"Zdravstveni centar, Valjevo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Lekovic","sequence":"additional","affiliation":[{"name":"Univerzitetska de\u010dja klinika, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Ristic","sequence":"additional","affiliation":[{"name":"Univerzitetska de\u010dja klinika, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momcilo","family":"Pavlovic","sequence":"additional","affiliation":[{"name":"Op\u0161ta bolnica, Subotica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zorica","family":"Stojsic","sequence":"additional","affiliation":[{"name":"Institut za patologiju, Medicinski fakultet, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Vuletic","sequence":"additional","affiliation":[{"name":"Pedijatrijska klinika, Klini\u010dki centar, Kragujevac"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Radlovic","sequence":"additional","affiliation":[{"name":"Univerzitetska de\u010dja klinika, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0609-9916","authenticated-orcid":false,"given":"Dejan","family":"Nikolic","sequence":"additional","affiliation":[{"name":"Univerzitetska de\u010dja klinika, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Djurdjevic","sequence":"additional","affiliation":[{"name":"Zavod za za\u0161titu radnika '\u017deleznica Srbije', Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Gajic","sequence":"additional","affiliation":[{"name":"Institut za statistiku, Medicinski fakultet, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4065\/74.6.613"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1996.0030"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00952.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010852"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809093898"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200109000-00023"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.983_f.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.47.6.1043"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701676138"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(00)00065-1"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200109000-00015"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199903000-00007"}],"container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:27:23Z","timestamp":1685356043000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81790902033R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":13,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh0902033r","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}