{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:12:17Z","timestamp":1773058337959,"version":"3.50.1"},"reference-count":5,"publisher":"National Library of Serbia","issue":"3-4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Introduction. Data on emergency interventions in poisonings are scarce. Objective. To determine the effectiveness of antidote therapy in acute poisoning-related emergency medical services (EMS) interventions. Methods. A prospective observational study included all poisoning-related intervention cases over 3 years (1999-2001) in the Celje region, Slovenia, covering 125,000 inhabitants. Data were recorded on an EMS form. Results. Psychoactive agents were present in 56.5% out of 244 poisoning-related EMS interventions. Prescription drugs were a cause of intoxication in 93 (39.2%) cases alone or in combination with alcohol or illegal drugs. More than one fifth of poisonings were due to the use of illegal drugs in 52 (21.9%) cases, 43 (18.1%) out of them heroin related. At the time of EMS arrival, more patients who ingested illegal drugs were in coma or comatose than the rest. 24 (45.3%) vs. 32 (17.3%) of poisoned patients were in coma (p&lt;0.001). Glasgow Coma Scale (GCS) at the first contact was lower in patients who ingested illegal drugs than in the remaining patients (9.0 vs. 11.6, p=0.001). In 23.2% of the cases, an antidote was administered. In 29 (12.2%) naloxone and in 16 (6.7%) flumazenil was administered. Mean GCS after intervention was higher in all cases but significantly higher in illegal drug cases, 13.4 vs. 12.2 (p=0.001), with a mean positive change in GCS of 4.5 vs. 0.6 (p&lt;0.001). In illegal drug users, mean change after antidote administration was 8.2 vs. 0.5 without antidote administration (p&lt;0.001). Conclusion. High rate of successful antidote use during the intervention indicated the importance of good EMS protocols and the presence of a skilled doctor in the EMS team.<\/jats:p>","DOI":"10.2298\/sarh1004210p","type":"journal-article","created":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T08:36:07Z","timestamp":1274690167000},"page":"210-213","source":"Crossref","is-referenced-by-count":3,"title":["Glasgow coma scale in acute poisonings before and after use of antidote in patients with history of use of psychotropic agents"],"prefix":"10.2298","volume":"138","author":[{"given":"Tonka","family":"Poplas-Susic","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zalika","family":"Klemenc-Ketis","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Komericki-Grzinic","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janko","family":"Kersnik","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Ljubljana, Slovenia + Department of Family Medicine, Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.2.577"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(05)70333-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hci089"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2004.tb00783.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmn009"}],"container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:28:45Z","timestamp":1685356125000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791004210P"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":5,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1004210p","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}