{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T05:57:41Z","timestamp":1725515861560},"reference-count":21,"publisher":"National Library of Serbia","issue":"9-10","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Antiphospholipid syndrome (APS) is an autoimmune disease with recurrent\n   thromboses and pregnancy complications (90% are female patients) that can be\n   primary and secondary (with concomitant autoimmune disease). Antiphospholipid\n   antibodies are prothrombotic but also act directly with brain tissue. One\n   clinical and one laboratory criterion is necessary for the diagnosis of APS.\n   Positive serological tests have to be confirmed after at least 12 weeks.\n   Clinical picture consists of thromboses in many organs and spontaneous\n   miscarriages, sometimes thrombocytopaenia and haemolytic anaemia, but\n   neurological cases are the most frequent: headaches, stroke, encephalopathy,\n   seizures, visual disturbances, Sneddon syndrome, dementia, vertigo, chorea,\n   balism, transitory global amnesia, psychosis, transversal myelopathy and\n   Guillain-Barre syndrome. About 50% of strokes below 50 years of age are\n   caused by APS. The first line of therapy in stroke is anticoagulation:\n   intravenous heparin or low-weight heparins. In chronic treatment, oral\n   anticoagulation and antiplatelet therapy are used, warfarin and aspirin,\n   mostly for life. In resistant cases, corticosteroids, intravenous\n   immunoglobulins and plasmapheresis are necessary. Prognosis is good in most\n   patients but some are treatment-resistant with recurrent thrombotic events\n   and eventually death.<\/jats:p>","DOI":"10.2298\/sarh1010651p","type":"journal-article","created":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T08:07:31Z","timestamp":1290758851000},"page":"651-657","source":"Crossref","is-referenced-by-count":1,"title":["Antiphospholipid syndrome"],"prefix":"10.2298","volume":"138","author":[{"suffix":"M.","given":"Dragan","family":"Pavlovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"M.","given":"Aleksandra","family":"Pavlovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0740"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1142018"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-6-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.02.012"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.05.015"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0778-2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03274.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.06.018"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/art.10187"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2005.03.009"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh408"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2007.48.6.901"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.07.008"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.6.834"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02373.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.08.003"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.061671"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.006163"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504133321504"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000170645.40562.09"}],"container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:29:21Z","timestamp":1685356161000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791010651P"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":21,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1010651p","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}