{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:17:15Z","timestamp":1790201835332,"version":"4.1.0"},"reference-count":0,"publisher":"National Library of Serbia","issue":"suppl. 1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Introduction. The optimal treatment of pregnancy associated VTE (venous\n   thromboembolism) has not been established yet. Objective. The assessment of\n   the efficacy and safety of low molecular weight heparin (LMWH) nadroparin and\n   unfractionated heparin (UFH) used for the treatment of pregnancy and\n   puerperium related VTE. Primary study goals were to analyze the incidence of\n   recurrent VTE (proximal extension or pulmonary thromboembolism),\n   thrombocytopenia, major and minor hemorrhages and skin allergic reactions.\n   The study also included the incidence of miscarriages, stillbirth and\n   neonatal abnormalities. We also studied the relationship between the presence\n   of thrombophilia and the occurrence of complications during VTE treatment.\n   Methods. Seventy-two women with antepartal VTE treated with s.c. LMWH during\n   entire pregnancy and 88 women with postpartal VTE initially treated with\n   either s.c. LMWH or i.v.UFH were under follow-up during the entire treatment.\n   Thrombophilia testing included antithrombin, protein C and protein S activity\n   levels, Activated protein C (APC) resistance, LA, ACL, FV Leiden, FII G20210A\n   and MTHFR C677T mutations. Results. Twice a day weight based therapeutic\n   regimen was applied for LMWH and activated partial thromboplastin time (aPTT)\n   adjusted UFH dosages. After 2-6 weeks of antepartal deep vein thrombosis\n   (DVT) treatment the dose of nadroparin was reduced to intermediate level. The\n   duration of LMWH therapy during pregnancy was 1-35 weeks, on average 16\n   weeks. One case (0.62%) of DVT propagation into the vena cava occurred in a\n   woman with antithrombin deficiency treated with LMWH. Two women (1.25%) had\n   minor bleeding and 5 (3.125%) had minimal bleeding, while 3 (1.9%) had skin\n   allergic reactions. The rate of successful pregnancy outcome was 97.2%. There\n   were no cases of stillbirth or neonatal congenital abnormalities.\n   Thrombophilia was found in 86 women (53.7%). No statistically significant\n   correlation between the presence of thrombophilia and treatment complications\n   were found. Conclusion. Nadroparin is both safe and effective for the\n   treatment of DVT during pregnancy and puerperium.<\/jats:p>","DOI":"10.2298\/sarh10s1018m","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T12:52:43Z","timestamp":1437569563000},"page":"18-22","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of nadroparin and unfractionated heparin for the treatment of venous thromboembolism during pregnancy and puerperium"],"prefix":"10.2298","volume":"138","author":[{"given":"Gorana","family":"Mitic","sequence":"first","affiliation":[{"name":"Clinical Centre of Vojvodina, Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Kovac","sequence":"additional","affiliation":[{"name":"Blood Transfusion Institute of Serbia, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubica","family":"Povazan","sequence":"additional","affiliation":[{"name":"Clinical Centre of Vojvodina, Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Djordjevic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1119-1343","authenticated-orcid":false,"given":"Vesna","family":"Ilic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Salatic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Vojvodina, Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radmila","family":"Lazic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Vojvodina, Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebojsa","family":"Antonijevic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Serbia, Institute of Cardiovascular Diseases, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Novakov-Mikic","sequence":"additional","affiliation":[{"name":"Clinical Centre of Vojvodina, Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:28:26Z","timestamp":1685356106000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817910018M"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"journal-issue":{"issue":"suppl. 1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh10s1018m","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}