{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T13:44:33Z","timestamp":1707399873907},"reference-count":0,"publisher":"National Library of Serbia","issue":"suppl. 1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Introduction. Hepatic veno-occlusive disease (VOD) is a life threatening\n   complication after stem cells transplantation (SCT). Its prediction, precise\n   diagnosis and treatment remain unclear. Objective. Our goals were to\n   determine the incidence, outcome and changes in haemostatic parameters in\n   patients with VOD. Also, we tried to determine coagulation disturbances and\n   their practical significance in early diagnosis of such patients. Methods. We\n   prospectively evaluated all consecutive VOD patients after SCT, aged 3 months\n   to 17 years, from February 2004 to July 2008 treated at the Mother and Child\n   Health Institute of Serbia ?Dr Vukan Cupic? (IMD). All patients were\n   diagnosed according to the Seattle criteria. The values of PT, aPTT,\n   fibrinogen, FVIII, AT and vWF were measured on the day prior to the\n   initiation of conditioning regiment and on the days 1, 7 and 14 from the\n   moment of VOD diagnosis. Laboratory testing was performed in the IMD\n   haemostasis laboratory and results were statistically evaluated. Results.\n   During the study period 74 SCT were performed at IMD. VOD developed 11\n   patients; 10 of 46 were autologous and 1 of 28 allogeneic SCT patients. In\n   our group of patients the incidence of VOD was 14.8%. VOD was classified as\n   mild in 7, moderate in 1 and severe in 3 patients. At the moment of\n   establishing the diagnosis all patients had a significantly increased\n   activity of vWF, FVIII and fibrinogen, and decreased AT. All of them were\n   dependent on platelet transfusions. Conclusion. Platelet transfusion\n   dependence suggests coagulation activation with great significance and\n   indicates a possible development of VOD. Our results also suggest that\n   monitoring coagulation parameters levels in the first five days from the\n   establishment of diagnosis may have a significant predictive value for VOD\n   outcome.<\/jats:p>","DOI":"10.2298\/sarh10s1033j","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T12:52:43Z","timestamp":1437569563000},"page":"33-38","source":"Crossref","is-referenced-by-count":4,"title":["Coagulation disturbances in paediatric patients with hepatic veno-occlusive disease after stem cells transplantation"],"prefix":"10.2298","volume":"138","author":[{"given":"Dragana","family":"Jevtic","sequence":"first","affiliation":[{"name":"Mother and Child Health Institute of Serbia \u201cDr. Vukan \u010cupi\u0107\u201d, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Vujic","sequence":"additional","affiliation":[{"name":"Mother and Child Health Institute of Serbia \u201cDr. Vukan \u010cupi\u0107\u201d, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeljko","family":"Zecevic","sequence":"additional","affiliation":[{"name":"Mother and Child Health Institute of Serbia \u201cDr. Vukan \u010cupi\u0107\u201d, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dobrila","family":"Veljkovic","sequence":"additional","affiliation":[{"name":"Mother and Child Health Institute of Serbia \u201cDr. Vukan \u010cupi\u0107\u201d, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Gazikalovic","sequence":"additional","affiliation":[{"name":"Mother and Child Health Institute of Serbia \u201cDr. Vukan \u010cupi\u0107\u201d, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Elezovic","sequence":"additional","affiliation":[{"name":"School of Medicine, Clinical Centre of Serbia, Institute of Haematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:28:37Z","timestamp":1685356117000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817910033J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"journal-issue":{"issue":"suppl. 1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh10s1033j","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}