{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:28:52Z","timestamp":1745494132025},"reference-count":0,"publisher":"National Library of Serbia","issue":"suppl. 1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>One of the best procedures to prevent haemarthrosis in haemophilia has been\n   radioactive synovectomy (radiosynoviorthesis). Since 1976 we have performed\n   119 radiosynoviortheses in 110 patients, aged from 3 to 40 years (mean 10),\n   and of whom 71 were under 12 years of age. The knees were injected in 71,\n   elbow in 29, ankles in 16, and shoulders in 3 cases. Clinical results of the\n   procedure gave excellent results 80% of patients with no further bleeding. In\n   the case of failure a reinjection can be given in the same joint at a 6 month\n   interval. One of the criticisms against this method is possible chromosomal\n   damage. In our centre, 4 studies have been made in order to see whether these\n   changes are permanent, but all have demonstrated that chromosomal changes are\n   reversible. Radioactive material used in 2 studies was Au-189. In 1978, 354\n   metaphases were studied with 61 ruptures, with 17.23% non-premalignant and 6\n   structural changes considered premalignant (1.69%). Further study was done in\n   1982, in the same group of patients with the result of 21 ruptures (3.34%)\n   and no structural changes. The third study was performed in 13 patients that\n   sustained radiosynoviorthesis with Re-186 in 1991. We compared the\n   chromosomal study before and 6 months after the radioactive material\n   injection and the results confirmed that changes appeared equally in\n   non-irradiated and radiated patients and disappeared with time, never\n   reaching the dangerous zone of 2%. In the group treated with Re-186 we\n   studied an additional number of 130 metaphases with identical results and no\n   structural changes. A study performed before and after radiosynoviorthesis\n   with Y-90 revealed no premalignant changes. It seems than radiosynoviorthesis\n   is safe and highly beneficial to haemophilic patients.<\/jats:p>","DOI":"10.2298\/sarh10s1039f","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T12:52:43Z","timestamp":1437569563000},"page":"39-42","source":"Crossref","is-referenced-by-count":7,"title":["Radiosynoviorthesis in haemophilia: How safe?"],"prefix":"10.2298","volume":"138","author":[{"given":"Federico","family":"Fern\u00e1ndez-Palazzi","sequence":"first","affiliation":[{"name":"Municipal Blood Bank, National Haemophilia Centre, Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Viso","sequence":"additional","affiliation":[{"name":"Municipal Blood Bank, National Haemophilia Centre, Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Absara","family":"Boadas","sequence":"additional","affiliation":[{"name":"Municipal Blood Bank, National Haemophilia Centre, Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlette","family":"Ruiz-Saez","sequence":"additional","affiliation":[{"name":"Municipal Blood Bank, National Haemophilia Centre, Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Aida","given":"Vargas","family":"de","sequence":"additional","affiliation":[{"name":"Municipal Blood Bank, National Haemophilia Centre, Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Norma","given":"Bosch","family":"de","sequence":"additional","affiliation":[{"name":"Municipal Blood Bank, National Haemophilia Centre, Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:28:38Z","timestamp":1685356118000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-817910039F"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"journal-issue":{"issue":"suppl. 1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh10s1039f","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}