{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:10:51Z","timestamp":1685358651874},"reference-count":9,"publisher":"National Library of Serbia","issue":"1-2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Introduction. Waldenstr?m?s macroglobulinaemia is a rare B cell\n   lymphoproliferative disorder characterized by lymphoplasmocyte bone marrow\n   infiltration and monoclonal IgM gammopathy. In the majority of cases,\n   Waldenstr?m?s macroglobulinaemia is a chronic disease with variable course.\n   Therapy consists of alkylating agents, purine analogs and antiCD20 monoclonal\n   antibody. In the literature, there have been descriptions of rare cases of\n   progression of Waldenstr?m?s macroglobulinaemia to aggressive lymphoma, as\n   well as secondary carcinoma in the patients after treatment of\n   macroglobulinaemia. Case Outline. A 63-year-old patient was diagnosed with\n   serum monoclonal IgM kappa gammopathy (Waldenstr?m?s macroglobulinaemia).\n   Chemotherapy was applied and a good clinical and haematological response had\n   been achieved. Ten years later, the patient was diagnosed with colon\n   adenocarcinoma as a secondary malignancy, and operated on. Within one month,\n   the patient rapidly developed a large neck tumour mass. Tumour biopsy\n   revealed the diagnosis of diffuse large B cell lymphoma with the expression\n   of monoclonal lambda chain, which more likely pointed out to coexistence of\n   two different B cell lymphoproliferative disorders, rather than the\n   transformation of Waldenstr?m?s macroglobulinaemia to aggressive lymphoma.\n   The patient was treated with chemotherapy following R-CHOP protocol, and\n   clinical remission was achieved. Seven months later, despite the successful\n   treatment of lymphoproliferative disorder, dissemination of adenocarcinoma\n   led to the lethal outcome. Conclusion. The patient was diagnosed with a rare\n   occurrence of three neoplastic diseases: Waldenstr?m?s macroglobulinaemia,\n   colon adenocarcinoma and diffuse large B cell lymphoma. The possible\n   mechanisms of the combined appearance of lymphoproliferative and other\n   malignant diseases include the previous treatment with alkylating agents,\n   genetic, immunomodulatory and environmental factors.<\/jats:p>","DOI":"10.2298\/sarh1102095r","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T07:36:29Z","timestamp":1304062589000},"page":"95-98","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse large cell lymphoma and colon adenocarcinoma in patient with Waldenstr\u00f6m\u2019s macroglobulinaemia"],"prefix":"10.2298","volume":"139","author":[{"given":"Milica","family":"Radojkovic","sequence":"first","affiliation":[{"name":"Klinika za internu medicinu, Klini\u010dko-bolni\u010dki centar \u201eDr Dragi\u0161a Mi\u0161ovi\u0107\u201d, Beograd + Medicinski fakultet, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Ristic","sequence":"additional","affiliation":[{"name":"Klinika za internu medicinu, Klini\u010dko-bolni\u010dki centar \u201eDr Dragi\u0161a Mi\u0161ovi\u0107\u201d, Beograd + Medicinski fakultet, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasa","family":"Colovic","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Beograd + Institut za hematologiju, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Cemerikic-Martinovic","sequence":"additional","affiliation":[{"name":"Histolab, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Colovic","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Beograd + Institut za hematologiju, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1309\/R01VXG46MFCDVNHL"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12120"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.261"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00810.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.43.131"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705944"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.1530"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63708-X"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-009-9170-7"}],"container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:29:38Z","timestamp":1685356178000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791102095R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":9,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1102095r","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}