{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:46:30Z","timestamp":1792071990689,"version":"4.4.0"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11-12","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Introduction. Chronic lymphocytic leukaemia is a disease with heterogeneous\n   clinical course and outcome. Some patients have a progressive course of the\n   disease and require therapy immediately after the diagnosis, while others\n   have a stable form without the need for treatment. Recently, two new\n   biological markers, the expression of CD38 antigen and ZAP-70 have shown\n   independent significance in the prognosis in CLL patients. Objective. The aim\n   of our study was to evaluate the clinical value of CD38 antigen and ZAP-70\n   expression as predictors of the disease progression and to analyze the\n   correlation of these markers with other B-CLL prognostic markers. Methods. We\n   assessed the expression of CD38 antigens by flow cytometry on peripheral\n   blood samples and the expression of ZAP-70 by immunohistochemistry on\n   formalin-fixed bone marrow (BM) biopsies in 40 newly diagnosed B-CLL\n   patients. Disease progression was defined by the period elapsed from\n   diagnosis to the time to first treatment (TFT). Results. Expression of CD38\n   antigen correlated positively with ZAP-70 expression (Pearson, r=0.476;\n   p=0.002). Also, correlation analysis results showed that a positive\n   expression of CD38 and ZAP-70 statistically significantly correlated with\n   unfavourable classical prognostic parameters, such as advanced Binet stage C,\n   diffuse BM infiltration, increased lactate-dehydrogenase and beta-2\n   microglobulin serum levels. Patients with positive expression of CD38 antigen\n   and ZAP-70 had a shorter TFT (log rank, 0.003 vs. 0.049). Conclusion. Both\n   new biological markers were shown to have an exceptional significance in the\n   prediction of prognosis in CLL patients.<\/jats:p>","DOI":"10.2298\/sarh1112753l","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T14:51:38Z","timestamp":1326898298000},"page":"753-758","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic significance of new biological markers in chronic lymphocytic leukaemia"],"prefix":"10.2298","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6194-8298","authenticated-orcid":false,"given":"Danijela","family":"Lekovic","sequence":"first","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5861-373X","authenticated-orcid":false,"given":"Biljana","family":"Mihaljevic","sequence":"additional","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Kraguljac-Kurtovic","sequence":"additional","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Perunicic-Jovanovic","sequence":"additional","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-7308","authenticated-orcid":false,"given":"Andrija","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Colovic","sequence":"additional","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8590-0328","authenticated-orcid":false,"given":"Mirjana","family":"Gotic","sequence":"additional","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:31:03Z","timestamp":1685356263000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791112753L"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":0,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1112753l","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}