{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:56:12Z","timestamp":1747209372774,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11-12","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Introduction. Granulocytic sarcoma, chloroma or myeloblastoma are observed in\n   3% to7% of acute myeloid leukaemia and represents localized tumour composed\n   of collection of immature leukaemic cells. It appears most frequently in\n   patients with M2, M4 and M5 subtypes of acute myeloid leukaemia Case Outline.\n   A 58-year-old female presented with pain and oedema of the right upper limb\n   in November 2009. After two months the patinet had fracture dislocation and\n   numerous osteolytic lesions of the right femur. Immunohistochemistry of\n   tumour biopsy showed megakaryoblastic granulocytic sarcoma which was CD31++,\n   F-XIII++, CD34-, FVIII+++, S100-, aktin-, EMA++, Bcl2++, CD43++, with\n   positive proliferative marker measured with Ki-67 positivity in more of 50%\n   of cells. Aspirate of bone marrow and immunophenotyping with flowcytometry\n   revealed diagnosis of acute megakaryoblastic leukaemia. The course of the\n   disease was rapid and the patient died before commencing chemotherapy, five\n   months after first complaints. Conclusion. Granulocytic sarcoma is\n   extramedullary localization of collection of leukaemia cells which can\n   proceed, to arise concomitantly with leukaemia, or may be the only\n   manifestation of the disease. The diagnosis can be established only with\n   immunohystochemistry.<\/jats:p>","DOI":"10.2298\/sarh1112805c","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T14:51:38Z","timestamp":1326898298000},"page":"805-808","source":"Crossref","is-referenced-by-count":1,"title":["Granulocytic sarcoma of the femur in a patient with acute megakaryoblastic leukaemia"],"prefix":"10.2298","volume":"139","author":[{"given":"Natasa","family":"Colovic","sequence":"first","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd + Medicinski fakultet, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-7308","authenticated-orcid":false,"given":"Andrija","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd + Medicinski fakultet, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Vidovic","sequence":"additional","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd + Medicinski fakultet, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Perunicic-Jovanovic","sequence":"additional","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Colovic","sequence":"additional","affiliation":[{"name":"Klinika za hematologiju, Klini\u010dki centar Srbije, Beograd + Medicinski fakultet, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:31:11Z","timestamp":1685356271000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791112805C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":0,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1112805c","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"type":"print","value":"0370-8179"},{"type":"electronic","value":"2406-0895"}],"subject":[],"published":{"date-parts":[[2011]]}}}