{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:56:19Z","timestamp":1747209379280,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"9-10","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Introduction. In the last few years the use of cardiac troponin I and T, as\n   diagnostic and prognostic factors of ischemic myocardial injury both in adult\n   and neonatal medicine has been of great interest. Objective. The objective of\n   our research was to investigate the significance of cardiac troponin I (sTnI)\n   as an early indicator of the presence and severity of hypoxic-ischemic\n   encephalopathy (HIE) in newborns. Methods. We analyzed 55 term newborns with\n   HIE diagnosed based on clinical findings and ultrasonographic examination of\n   the central nervous system. Serum concentration of sTnIultra was determined\n   by immunoenzyme method during the first 24-48 hours after birth, and the\n   obtained findings were compared with the values of identical parameter in 36\n   healthy term newborns. Results. During the first 24-48 hrs after birth, serum\n   concentration of sTnI-ultra was significantly higher (r&lt;0.0005) in term\n   newborns with HIE (0.135?0.207 ?g\/l) and median (0.07, 0.01- 006 ?g\/l) in\n   comparison to control group (0.0183?0.026 ?g\/l and median 0.01 (0.01-0.01\n   ?g\/l), with the sTnI-ultra level rising proportionally to the clinical HIE\n   stages. The increase of sTnI-ultra of &gt;0.12 ?g\/l indicated the development of\n   significant cerebral damage with the sensitivity of 75% and specificity of\n   72.2%, while the sTnI-ultra level of &gt;0.13 ?g\/l was a significant mortality\n   predictor with sensitivity of 76.9% and specificity of 73.8%. Conclusion. The\n   second generation cardiac troponin I assay highly correlates with clinical\n   and ultrasonographic findings in neonates with HIE, so that it can be used as\n   a significant diagnostic and prognostic indicator of this pathological\n   condition.<\/jats:p>","DOI":"10.2298\/sarh1210600s","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T08:53:05Z","timestamp":1353919985000},"page":"600-605","source":"Crossref","is-referenced-by-count":3,"title":["The significance of second generation cardiac troponin I in early screening of hypoxic-ischemic encephalopathy after perinatal asphyxia"],"prefix":"10.2298","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-1972","authenticated-orcid":false,"suffix":"M.","given":"Aleksandra","family":"Simovic","sequence":"first","affiliation":[{"name":"Klinika za pedijatriju, Klini\u010dki centar \u201eKragujevac\u201c, Kragujevac + Medicinski fakultet, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-6475","authenticated-orcid":false,"given":"Zoran","family":"Igrutinovic","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klini\u010dki centar \u201eKragujevac\u201c, Kragujevac + Medicinski fakultet, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Obradovic","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klini\u010dki centar \u201eKragujevac\u201c, Kragujevac + Medicinski fakultet, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Ristic","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klini\u010dki centar \u201eKragujevac\u201c, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biljana","family":"Vuletic","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klini\u010dki centar \u201eKragujevac\u201c, Kragujevac + Medicinski fakultet, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Radovanovic","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klini\u010dki centar \u201eKragujevac\u201c, Kragujevac + Medicinski fakultet, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:32:38Z","timestamp":1685356358000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791210600S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":0,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1210600s","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"type":"print","value":"0370-8179"},{"type":"electronic","value":"2406-0895"}],"subject":[],"published":{"date-parts":[[2012]]}}}