{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:08:14Z","timestamp":1685419694807},"reference-count":0,"publisher":"National Library of Serbia","issue":"9-10","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Introduction. Chronic hepatitis C virus (HCV) infection can progress to liver\n   cirrhosis that causes bleeding from the gastrointestinal tract, liver failure\n   and primary hepatocellular carcinoma. Use of standard therapeutic option\n   consists of recombinant pegylated interferon alpha 2a\/b with ribavirin in\n   order to eradicate virus and prevent complications. Objective. The aim of\n   investigation was to evaluate efficiency of combination therapy (pegylated\n   interferon alpha 2a\/b plus ribavirin) in patients with chronic HCV infection\n   and to estimate predictive factors for successful treatment. Methods. A total\n   of 387 patients with confirmed diagnosis of hepatitis C were evaluated (aged\n   18-65 years of both genders). Patients were treated with pegylated\n   interferon alpha 2a\/b and ribavirin according to a standard regimen lasting\n   24 or 48 weeks, dependent on virus genotype. Results. Negative HCV RNA (PCR\n   assay) was recorded in 79.7% of patients at the end of treatment. Six months\n   after completed therapy, negative HCV RNA, i.e. stained virologic response\n   (SVR) was assessed in 70.5% of patients. Statistical summary of our results\n   concerning SVR confirmed better efficiency of combination therapy for the\n   following parameters compared to other investigated variables: age ?40 (84.3%\n   vs. 59.l%; p&lt;0.0005), absence of cirrhosis (75.6% vs. 58.3%; p=0.003), lack\n   of genotype 1 (86.6% vs. 61.8%; p&lt;0.0005), and in patients who received full\n   doses of pegylated interferon alpha 2a (78.3% vs. 63.3%; p=0.002).\n   Conclusion. Combination therapy of recombinant pegylated interferon alpha 2a\n   with ribavirin leads to SVR in the majority of treated patients (70.5%).\n   Successful treatment depends on a variety of host and virus factors.<\/jats:p>","DOI":"10.2298\/sarh1210612d","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T08:53:05Z","timestamp":1353919985000},"page":"612-618","source":"Crossref","is-referenced-by-count":0,"title":["Antiviral\/immunomodulatory combination therapy: Pegylated interferon alpha 2a and ribavirin in patients with chronic hepatitis C virus infection"],"prefix":"10.2298","volume":"140","author":[{"given":"Dragan","family":"Delic","sequence":"first","affiliation":[{"name":"Medicinski fakultet, Beograd + Klinika za infektivne i tropske bolesti, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"Mitrovic","sequence":"additional","affiliation":[{"name":"Klinika za infektivne i tropske bolesti, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasa","family":"Popovic","sequence":"additional","affiliation":[{"name":"Klinika za infektivne i tropske bolesti, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Urosevic","sequence":"additional","affiliation":[{"name":"Klinika za infektivne i tropske bolesti, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Pesic","sequence":"additional","affiliation":[{"name":"Klinika za infektivne i tropske bolesti, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmina","family":"Simonovic","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Beograd + Klinika za infektivne i tropske bolesti, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Dulovic","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Beograd + Klinika za infektivne i tropske bolesti, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Svirtlih","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Beograd + Klinika za infektivne i tropske bolesti, Klini\u010dki centar Srbije, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:32:39Z","timestamp":1685356359000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791210612D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":0,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1210612d","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}